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CD59 (PNH Marker)

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CD59 (PNH Marker), in Bangalore

Measures CD59 protein on blood cells to detect PNH and assess risk of complement-driven red cell destruction.

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SAMPLE TYPE
Blood
FASTING REQUIRED
No
GENDER
Male/Female
GET REPORTS IN
25 hours
TEST INCLUDED
1
customers
20K+Customers
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CertifiedLabs
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4.5+Rating
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ProvenAccuracy

What is a CD59 (PNH Marker) Test in Bangalore ?

The CD59 (PNH Marker) test measures the presence of the CD59 protein on blood cell surfaces. CD59 helps protect red blood cells and other cells from being destroyed by the complement system. Losing CD59 on cells is a key sign of paroxysmal nocturnal hemoglobinuria (PNH). PNH can cause dark urine, anemia, fatigue, and dangerous blood clots. Doctors use this test with flow cytometry to find and measure PNH cell clones. It helps confirm diagnosis, guide treatment choices, and monitor response to therapies that block complement activity. The test is often done with CD55 and other markers to give a clear picture of cell protection loss.

CD59 (PNH Marker) Test Preparation in Bangalore

No special preparation is required.

CD59 (PNH Marker) Test Parameters in Bangalore

The CD59 (PNH Marker) test evaluates various parameters related to the different components. Here are the main parameters that are checked in the test:

  • Single test

Why Take a CD59 (PNH Marker) Test in Bangalore ?

CD59 (PNH Marker) is usually ordered as part of a PNH flow cytometry panel when doctors suspect abnormal red cell breakdown, dark urine, unexplained anemia, or unusual blood clots. It helps diagnose and monitor paroxysmal nocturnal hemoglobinuria and guide treatment with complement inhibitors. Abnormal results come from acquired loss of GPI-anchored proteins due to bone marrow cell mutations, and rarely from lab technical issues. A family history of bone marrow disorders may prompt testing.

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Frequently asked questions

For any unanswered questions, reach out to our support team via email. We will assist you as soon as possible

What is CD59 a marker for in Bangalore?plus

CD59 (protectin) is a glycosylphosphatidylinositol‑anchored membrane protein that inhibits formation of the membrane attack complex, protecting host cells from complement‑mediated lysis. It is widely expressed on erythrocytes, leukocytes and endothelial cells and is used clinically as a surface marker in flow cytometry. Loss or deficiency of CD59 on red cells is diagnostic for paroxysmal nocturnal hemoglobinuria.

What are the markers for PNH in Bangalore?plus

Key markers for paroxysmal nocturnal hemoglobinuria (PNH) include loss or reduction of GPI‑anchored proteins—especially CD55 and CD59—on red cells, granulocytes and monocytes by flow cytometry. Laboratory findings: hemoglobinuria/urinary hemosiderin, elevated LDH, low haptoglobin, indirect hyperbilirubinemia, reticulocytosis, and cytopenias. There is also increased thrombotic risk with raised D‑dimer.

What is the role of CD55 in PNH in Bangalore?plus

CD55 (decay-accelerating factor) protects blood cells from complement by accelerating decay of C3/C5 convertases on cell surfaces. In PNH, GPI-anchor deficiency causes loss of CD55 (and CD59) on red cells, permitting uncontrolled complement activation and membrane attack complex formation. This leads to intravascular hemolysis, hemoglobinuria, and increased risk of thrombosis and other PNH complications.

What is the role of CD55 and CD59 in Bangalore?plus

CD55 (decay-accelerating factor) and CD59 (protectin) are membrane proteins that protect host cells from complement-mediated damage. CD55 disrupts C3/C5 convertases to limit opsonization and downstream complement activation. CD59 blocks terminal complement complex assembly by preventing C9 polymerization, stopping membrane attack complex formation. Loss of these proteins (e.g., in paroxysmal nocturnal hemoglobinuria) causes complement-driven red cell lysis.

What is the hallmark of PNH in Bangalore?plus

The hallmark of paroxysmal nocturnal hemoglobinuria (PNH) is complement‑mediated intravascular hemolysis due to acquired PIGA gene mutations that cause loss of GPI‑anchored proteins, chiefly CD55 and CD59, on red blood cells. This renders RBCs hypersensitive to complement, causing hemoglobinuria (often worse at night), hemolytic anemia, and increased risk of thrombosis and bone marrow failure.

What is CD59 also known as in Bangalore?plus

CD59 is also known as protectin and as the membrane attack complex–inhibitory protein (MAC‑IP). It is often called CD59 glycoprotein or CD59 antigen. This small, GPI‑anchored complement regulatory protein prevents formation of the membrane attack complex on host cells, protecting them from complement‑mediated lysis. It is expressed widely on red blood cells, leukocytes, endothelial cells and many other tissues.

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Needed CD59 (PNH Marker) as part of a pre-surgery clearance checklist. GetVisit had an appointment available quickly. Home collection, report within hours, and the surgical team had everything on time.

Sundaram Tripathi

Bangalore

starstarstarstarstar

Post-illness recovery monitoring included CD59 (PNH Marker). My doctor wanted to check everything had returned to baseline. GetVisit, home collection, detailed report, and my doctor confirmed a full recovery at my follow-up.

Tara Shah

Bangalore

starstarstarstarstar

A friend who uses GetVisit regularly convinced me to try it for CD59 (PNH Marker). Glad I did, the home collection meant there was no excuse to delay, and the report arrived faster than I expected.

Balaji Chatterjee

Bangalore

starstarstarstarstar

Travel frequently and needed CD59 (PNH Marker) before a trip. GetVisit in Nagarbhavi, Bengaluru made the whole process so convenient for me. GetVisit, short-notice appointment, efficient collection, digital report on my phone. Exactly the flexibility I needed.

Sapna Tiwari

Bangalore

starstarstarstarstar

Made a commitment to be more proactive about health. CD59 (PNH Marker) through GetVisit is part of that, no excuses about lab distances, book online, collection at home, report before the day is done.

Chandni Kumar

Bangalore

starstarstarstarstar

My doctor ordered CD59 (PNH Marker) as part of a routine workup. The phlebotomist from GetVisit visited me in Bellandur, Bengaluru, on time and professional. GetVisit, technician arrived on time, professional collection, report within a few hours. My doctor was satisfied with the quality.

Rajiv Malviya

Bangalore

starstarstarstarstar

Family has been using GetVisit for all health tests for a year. CD59 (PNH Marker) for me, other tests for family members, professional technicians, reports our doctors consistently find reliable.

Sharada Prakash

Bangalore

starstarstarstarstar

Comprehensive annual health panel, CD59 (PNH Marker) was part of it. Used GetVisit on a family member's recommendation. Home collection at a convenient time, well-formatted report with values and reference ranges delivered digitally. Much easier than a lab visit.

Hiral Iyer

Bangalore

starstarstarstarstar

Hadn't done CD59 (PNH Marker) in two years. GetVisit's home collection removed every excuse, booked the night before, done at 7 am, report on email before noon. All within range. My doctor was relieved to have an updated picture.

Bikash Sharma

Bangalore

starstarstarstarstar

Started a new exercise programme and my trainer recommended checking CD59 (PNH Marker) for a baseline. GetVisit, home collection early morning, report by 9 am, and my trainer could design a nutrition plan.

Nisha Saxena

Bangalore

starstarstarstarstar

Needed CD59 (PNH Marker) as part of a pre-surgery clearance checklist. GetVisit had an appointment available quickly. Home collection, report within hours, and the surgical team had everything on time.

Sundaram Tripathi

Bangalore

starstarstarstarstar

Post-illness recovery monitoring included CD59 (PNH Marker). My doctor wanted to check everything had returned to baseline. GetVisit, home collection, detailed report, and my doctor confirmed a full recovery at my follow-up.

Tara Shah

Bangalore

starstarstarstarstar

A friend who uses GetVisit regularly convinced me to try it for CD59 (PNH Marker). Glad I did, the home collection meant there was no excuse to delay, and the report arrived faster than I expected.

Balaji Chatterjee

Bangalore

starstarstarstarstar

Travel frequently and needed CD59 (PNH Marker) before a trip. GetVisit in Nagarbhavi, Bengaluru made the whole process so convenient for me. GetVisit, short-notice appointment, efficient collection, digital report on my phone. Exactly the flexibility I needed.

Sapna Tiwari

Bangalore

starstarstarstarstar

Made a commitment to be more proactive about health. CD59 (PNH Marker) through GetVisit is part of that, no excuses about lab distances, book online, collection at home, report before the day is done.

Chandni Kumar

Bangalore

starstarstarstarstar

My doctor ordered CD59 (PNH Marker) as part of a routine workup. The phlebotomist from GetVisit visited me in Bellandur, Bengaluru, on time and professional. GetVisit, technician arrived on time, professional collection, report within a few hours. My doctor was satisfied with the quality.

Rajiv Malviya

Bangalore

starstarstarstarstar

Family has been using GetVisit for all health tests for a year. CD59 (PNH Marker) for me, other tests for family members, professional technicians, reports our doctors consistently find reliable.

Sharada Prakash

Bangalore

starstarstarstarstar

Comprehensive annual health panel, CD59 (PNH Marker) was part of it. Used GetVisit on a family member's recommendation. Home collection at a convenient time, well-formatted report with values and reference ranges delivered digitally. Much easier than a lab visit.

Hiral Iyer

Bangalore

starstarstarstarstar

Hadn't done CD59 (PNH Marker) in two years. GetVisit's home collection removed every excuse, booked the night before, done at 7 am, report on email before noon. All within range. My doctor was relieved to have an updated picture.

Bikash Sharma

Bangalore

starstarstarstarstar

Started a new exercise programme and my trainer recommended checking CD59 (PNH Marker) for a baseline. GetVisit, home collection early morning, report by 9 am, and my trainer could design a nutrition plan.

Nisha Saxena

Bangalore

starstarstarstarstar

Needed CD59 (PNH Marker) as part of a pre-surgery clearance checklist. GetVisit had an appointment available quickly. Home collection, report within hours, and the surgical team had everything on time.

Sundaram Tripathi

Bangalore

starstarstarstarstar

Post-illness recovery monitoring included CD59 (PNH Marker). My doctor wanted to check everything had returned to baseline. GetVisit, home collection, detailed report, and my doctor confirmed a full recovery at my follow-up.

Tara Shah

Bangalore

starstarstarstarstar

A friend who uses GetVisit regularly convinced me to try it for CD59 (PNH Marker). Glad I did, the home collection meant there was no excuse to delay, and the report arrived faster than I expected.

Balaji Chatterjee

Bangalore

starstarstarstarstar

Travel frequently and needed CD59 (PNH Marker) before a trip. GetVisit in Nagarbhavi, Bengaluru made the whole process so convenient for me. GetVisit, short-notice appointment, efficient collection, digital report on my phone. Exactly the flexibility I needed.

Sapna Tiwari

Bangalore

starstarstarstarstar

Made a commitment to be more proactive about health. CD59 (PNH Marker) through GetVisit is part of that, no excuses about lab distances, book online, collection at home, report before the day is done.

Chandni Kumar

Bangalore

starstarstarstarstar

My doctor ordered CD59 (PNH Marker) as part of a routine workup. The phlebotomist from GetVisit visited me in Bellandur, Bengaluru, on time and professional. GetVisit, technician arrived on time, professional collection, report within a few hours. My doctor was satisfied with the quality.

Rajiv Malviya

Bangalore

starstarstarstarstar

Family has been using GetVisit for all health tests for a year. CD59 (PNH Marker) for me, other tests for family members, professional technicians, reports our doctors consistently find reliable.

Sharada Prakash

Bangalore

starstarstarstarstar

Comprehensive annual health panel, CD59 (PNH Marker) was part of it. Used GetVisit on a family member's recommendation. Home collection at a convenient time, well-formatted report with values and reference ranges delivered digitally. Much easier than a lab visit.

Hiral Iyer

Bangalore

starstarstarstarstar

Hadn't done CD59 (PNH Marker) in two years. GetVisit's home collection removed every excuse, booked the night before, done at 7 am, report on email before noon. All within range. My doctor was relieved to have an updated picture.

Bikash Sharma

Bangalore

starstarstarstarstar

Started a new exercise programme and my trainer recommended checking CD59 (PNH Marker) for a baseline. GetVisit, home collection early morning, report by 9 am, and my trainer could design a nutrition plan.

Nisha Saxena

Bangalore

starstarstarstarstar

Needed CD59 (PNH Marker) as part of a pre-surgery clearance checklist. GetVisit had an appointment available quickly. Home collection, report within hours, and the surgical team had everything on time.

Sundaram Tripathi

Bangalore

starstarstarstarstar

Post-illness recovery monitoring included CD59 (PNH Marker). My doctor wanted to check everything had returned to baseline. GetVisit, home collection, detailed report, and my doctor confirmed a full recovery at my follow-up.

Tara Shah

Bangalore

starstarstarstarstar

A friend who uses GetVisit regularly convinced me to try it for CD59 (PNH Marker). Glad I did, the home collection meant there was no excuse to delay, and the report arrived faster than I expected.

Balaji Chatterjee

Bangalore

starstarstarstarstar

Travel frequently and needed CD59 (PNH Marker) before a trip. GetVisit in Nagarbhavi, Bengaluru made the whole process so convenient for me. GetVisit, short-notice appointment, efficient collection, digital report on my phone. Exactly the flexibility I needed.

Sapna Tiwari

Bangalore

starstarstarstarstar

Made a commitment to be more proactive about health. CD59 (PNH Marker) through GetVisit is part of that, no excuses about lab distances, book online, collection at home, report before the day is done.

Chandni Kumar

Bangalore

starstarstarstarstar

My doctor ordered CD59 (PNH Marker) as part of a routine workup. The phlebotomist from GetVisit visited me in Bellandur, Bengaluru, on time and professional. GetVisit, technician arrived on time, professional collection, report within a few hours. My doctor was satisfied with the quality.

Rajiv Malviya

Bangalore

starstarstarstarstar

Family has been using GetVisit for all health tests for a year. CD59 (PNH Marker) for me, other tests for family members, professional technicians, reports our doctors consistently find reliable.

Sharada Prakash

Bangalore

starstarstarstarstar

Comprehensive annual health panel, CD59 (PNH Marker) was part of it. Used GetVisit on a family member's recommendation. Home collection at a convenient time, well-formatted report with values and reference ranges delivered digitally. Much easier than a lab visit.

Hiral Iyer

Bangalore

starstarstarstarstar

Hadn't done CD59 (PNH Marker) in two years. GetVisit's home collection removed every excuse, booked the night before, done at 7 am, report on email before noon. All within range. My doctor was relieved to have an updated picture.

Bikash Sharma

Bangalore

starstarstarstarstar

Started a new exercise programme and my trainer recommended checking CD59 (PNH Marker) for a baseline. GetVisit, home collection early morning, report by 9 am, and my trainer could design a nutrition plan.

Nisha Saxena

Bangalore