Androstenedione (A4)

Normal androstenedione varies by sex, age and laboratory method. Typical adult male values are roughly 85–400 ng/dL (≈3–14 nmol/L); adult female values are commonly about 40–250 ng/dL (≈1.4–8.7 nmol/L), with fluctuations across the menstrual cycle and lower levels after menopause. Pediatric ranges are lower. Always compare your result to the lab’s reference range and discuss abnormal values with a clinician.

Yes — androstenedione is commonly abbreviated A4 (also called 4-androstenedione or androst-4-ene-3,17-dione). It’s an endogenous steroid produced by the adrenal glands and gonads, acting as a prohormone that can be enzymatically converted into testosterone and estrogens (notably estrone). It’s integral to steroidogenesis and is measured when assessing adrenal or gonadal hormone disorders.

An A4 test is a simple, printable visual-acuity chart sized to A4 paper for basic home vision screening. It can reveal reduced clarity, blurriness, or distortion but isn’t a substitute for a professional eye exam. Accurate results need correct print scale and testing distance. If you notice persistent blurring, double vision, sudden changes, or other concerns, arrange a full eye assessment promptly.

An androstenedione test in females measures blood levels of androstenedione, an androgen produced by ovaries and adrenal glands. It's used to evaluate hirsutism, acne, virilization, irregular periods, suspected polycystic ovary syndrome, congenital adrenal hyperplasia, or adrenal/ovarian tumors. Results help distinguish ovarian vs adrenal sources and monitor treatment. Testing is a simple blood draw; interpretation considers age, menstrual phase, and medications.

Yes — androstenedione is often elevated in PCOS. Many people with PCOS have increased androstenedione alongside testosterone and DHEA‑S, contributing to hirsutism, acne and ovulatory dysfunction. Levels vary and a single measurement isn’t diagnostic; clinicians interpret androstenedione with other hormones and clinical signs. Management focuses on weight loss, combined oral contraceptives and anti‑androgen therapies when appropriate.

Elevated androstenedione can cause androgenic effects—acne, increased facial/body hair, scalp hair loss, and menstrual irregularities or infertility in women; in severe cases, virilization. Causes include polycystic ovary syndrome, adrenal disorders (including congenital adrenal hyperplasia), or androgen-secreting tumors. High levels may signal metabolic issues and require endocrine evaluation; diagnosis uses blood tests and imaging, with treatment aimed at the underlying cause.