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ROMA Index - OVARIAN MALIGNANCY RISK ALGORITHM

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ROMA Index - OVARIAN MALIGNANCY RISK ALGORITHM, in Visit Clinic

Combines two blood markers and menopausal status to estimate risk that an ovarian mass is cancerous in Visit Clinic.

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Blood

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GENDER

Female

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24 hours

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What is a ROMA Index - OVARIAN MALIGNANCY RISK ALGORITHM Test in Visit Clinic?

The ROMA Index measures two blood proteins, CA-125 and HE4, and combines them with menopausal status to estimate the chance an ovarian mass is cancerous. These markers can rise when ovarian cancer or other pelvic conditions are present. The score helps doctors decide who needs faster referral to a specialist and who may have lower risk. ROMA is not a definitive diagnosis. It is used together with ultrasound, physical exam, and symptoms to guide decisions about surgery, further testing, or monitoring. Results are one piece of the clinical picture and must be interpreted in context.

ROMA Index - OVARIAN MALIGNANCY RISK ALGORITHM Test Preparation in Visit Clinic

No special preparation is required.

ROMA Index - OVARIAN MALIGNANCY RISK ALGORITHM Test Parameters in Visit Clinic

The ROMA Index - OVARIAN MALIGNANCY RISK ALGORITHM test evaluates various parameters. Here are the main parameters checked:

CA-125

and a calculated risk score (ROMA)

Why Take a ROMA Index - OVARIAN MALIGNANCY RISK ALGORITHM Test in Visit Clinic?

ROMA Index - OVARIAN MALIGNANCY RISK ALGORITHM is usually used in the workup of a pelvic mass or suspected ovarian tumor. Doctors may order it when a woman has pelvic pain, bloating, abdominal swelling, or unexplained changes in menstrual or pelvic symptoms. It helps distinguish likely benign from possibly malignant masses. Abnormal results can come from ovarian cancer, but also from benign cysts, endometriosis, inflammation, or certain physiological states. A family history of ovarian or breast cancer makes this test more important.

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Frequently asked questions

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What is the Roma score for ovarian malignancy risk algorithm in Visit Clinic?

ROMA (Risk of Ovarian Malignancy Algorithm) combines serum HE4 and CA125 levels with menopausal status to estimate the probability of epithelial ovarian cancer. It uses logistic regression: premenopausal PI = −12.0 + 2.38·ln(HE4) + 0.0626·ln(CA125); postmenopausal PI = −8.09 + 1.04·ln(HE4) + 0.732·ln(CA125). ROMA% = exp(PI)/(1+exp(PI))×100; cutoffs: ≥11.4% (pre), ≥29.9% (post) indicate high risk.

What is the Roca algorithm for ovarian cancer in Visit Clinic?

ROCA (Risk of Ovarian Cancer Algorithm) is a statistical model that interprets serial CA‑125 blood levels over time to detect patterns suggestive of ovarian cancer. Using age and a Bayesian change‑point approach, it estimates individualized risk and classifies results to prompt repeat testing, transvaginal ultrasound, or specialist referral. It can identify rising trends earlier than a single cutoff, but isn’t endorsed for routine population screening.

How to calculate Roma score in Visit Clinic?

ROMA (Risk of Ovarian Malignancy Algorithm) uses serum HE4 and CA125 plus menopausal status. Compute the predictive index (PI): premenopausal PI = -12.0 + 2.38 × ln(HE4) + 0.0626 × ln(CA125); postmenopausal PI = -8.09 + 1.04 × ln(HE4) + 0.732 × ln(CA125). Convert to ROMA% = exp(PI)/(1+exp(PI)) × 100. Cutoffs: ≥11.4% (premenopausal) or ≥29.9% (postmenopausal) indicate high risk.

How to calculate risk of malignancy index in ovarian cancer in Visit Clinic?

RMI is calculated as RMI = U × M × CA125. Ultrasound score (U): 0 for no suspicious features, 1 for one feature, 3 for two or more (features: multilocularity, solid areas, bilaterality, ascites, metastases). Menopausal status (M): 1 if premenopausal, 3 if postmenopausal. Multiply by serum CA125 (U/ml); RMI ≥200 commonly indicates high malignancy risk.

What does a high Roma score mean in Visit Clinic?

A high ROMA score indicates an increased probability of epithelial ovarian malignancy. It’s calculated from blood markers (HE4 and CA125) plus menopausal status. A high result usually prompts further evaluation—imaging and referral to a gynecologic oncologist—but is not diagnostic by itself. Clinical assessment and additional tests are needed to confirm or exclude cancer.

What is the Roma scale in Visit Clinic?

The ROMA (Risk of Ovarian Malignancy Algorithm) scale combines blood levels of CA‑125 and HE4 with menopausal status to estimate a woman’s likelihood of having epithelial ovarian cancer. It yields a numeric risk score used to classify patients as low- or high-risk preoperatively and helps guide referral and management. It is an adjunct to imaging and clinical assessment, not a definitive diagnostic test.

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