Lab Tests

Myeloid Cell Marker / GIST Marker : CD 15

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Myeloid Cell Marker / GIST Marker : CD 15, in Visit Clinic

Measures CD15 on cell surfaces to help identify myeloid cells and assist in tumor and leukemia diagnosis in Visit Clinic.

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Tissue

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Male/Female

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26 hours

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What is a Myeloid Cell Marker / GIST Marker : CD 15 Test in Visit Clinic?

CD15 is a protein found on the surface of certain white blood cells, especially neutrophils and other myeloid cells. The test checks whether cells in a tissue, blood, or bone marrow sample show CD15 on their surface. It helps doctors identify cell types and classify tumors. CD15 is useful in evaluating myeloid leukemias, some lymphomas, and in tumor typing when used with other markers. Laboratories perform the test by staining tissue (immunohistochemistry) or by flow cytometry. Results help guide diagnosis, treatment choices, and ongoing monitoring. It is widely used.

Myeloid Cell Marker / GIST Marker : CD 15 Test Preparation in Visit Clinic

No special preparation is required.

Myeloid Cell Marker / GIST Marker : CD 15 Test Parameters in Visit Clinic

The Myeloid Cell Marker / GIST Marker : CD 15 test evaluates various parameters. Here are the main parameters checked:

Single test

Why Take a Myeloid Cell Marker / GIST Marker : CD 15 Test in Visit Clinic?

Myeloid Cell Marker / GIST Marker : CD 15 is often included in myeloid leukemia panels, lymphoma panels, or tumor immunohistochemistry panels. Doctors order it for unexplained low or high blood counts, swollen lymph nodes, or when examining a mass or biopsy. It helps diagnose or monitor myeloid leukemias, some lymphomas, and to help classify tumors. Abnormal results can come from infection, inflammation, or malignancy, and family history of blood cancers can prompt testing.

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Frequently asked questions

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Is CD15 a myeloid marker in Visit Clinic?

Yes. CD15 (Lewis X) is commonly used as a myeloid/granulocytic marker — strongly expressed on neutrophils and other granulocytes and often on myeloid-derived cells. However, it is not entirely specific: CD15 can appear on some monocytes and certain lymphoid or epithelial tumor cells (e.g., Reed–Sternberg cells), so interpretation should use additional markers and clinical context.

What does CD15 positive mean in Visit Clinic?

CD15 positive means cells express the CD15 surface antigen (a carbohydrate/Lewis X epitope) detected by immunohistochemistry or flow cytometry. CD15 is normally on granulocytes and some monocytes, and can be found on Reed–Sternberg cells and certain tumors. Its presence helps identify granulocytic/myeloid lineage, supporting diagnosis and classification of leukemias, lymphomas, and other cancers.

What is the function of the CD15 marker in Visit Clinic?

CD15 (Lewis X) is a carbohydrate surface marker on granulocytes, monocytes and some epithelial cells that mediates cell–cell adhesion and recognition. It promotes neutrophil trafficking and binding to endothelium during inflammation, facilitates phagocytosis and immune clearance, and is used diagnostically to identify myeloid-lineage cells and certain lymphoma subtypes. It also helps distinguish hematologic disease subtypes in pathology.

What tumors are CD15 positive in Visit Clinic?

CD15 (Lewis X) positivity is seen in classical Hodgkin lymphoma (Reed–Sternberg cells), many myeloid neoplasms (e.g., acute myeloid leukemia and myelomonocytic leukemias), and in various epithelial adenocarcinomas (notably colorectal and gastric; sometimes lung, pancreatic). It’s also expressed on normal granulocytes and is used diagnostically to indicate myeloid or Hodgkin phenotype.

Which CD markers indicate leukemia in Visit Clinic?

Leukemia immunophenotypes vary: B‑cell ALL—CD19, CD10, CD22, CD79a (±CD20); T‑cell ALL—CD2, CD3, CD5, CD7 (±CD1a); AML—myeloid markers CD13, CD33, CD117, and CD34 (blast marker); CLL—CD5, CD19, CD23 with dim CD20 and weak surface Ig; hairy cell leukemia—CD11c, CD25, CD103. CD45 is a common leukocyte marker. Flow cytometry guides diagnosis and therapy.

What is CD15 and CD30 in Visit Clinic?

CD15 and CD30 are cell-surface markers (clusters of differentiation) used in blood and cancer diagnostics. CD15 is a carbohydrate antigen (Lewis X) found on neutrophils, some monocytes and in Reed–Sternberg cells of classical Hodgkin lymphoma. CD30 is a transmembrane receptor in the TNF receptor family expressed on activated lymphocytes and on Reed–Sternberg and certain lymphoma cells; both aid diagnosis and guide therapy.

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