Lab Tests

Myeloid Cell Marker : CD 15

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Myeloid Cell Marker : CD 15, in Visit Clinic

Checks for the CD15 protein on myeloid (white blood) cells to help detect infection, inflammation, or blood cancers in Visit Clinic.

Centre Visit

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SAMPLE TYPE

Blood

FASTING REQUIRED

GENDER

Male/Female

GET REPORTS IN

27 hours

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What is a Myeloid Cell Marker : CD 15 Test in Visit Clinic?

The Myeloid Cell Marker CD15 test looks for the CD15 protein on certain white blood cells. CD15 is found mainly on granulocytes, a type of myeloid cell involved in fighting infection. Detecting CD15 helps doctors identify cells of myeloid origin and see whether abnormal cells are present. It helps in diagnosing and monitoring conditions like acute myeloid leukemia, myelodysplastic syndromes, and some lymphomas. It can also reflect inflammation or infection when granulocytes are activated. Clinicians use CD15 testing as part of immunophenotyping panels, flow cytometry, or tissue staining. Results help guide diagnosis, treatment choices, and follow-up care.

Myeloid Cell Marker : CD 15 Test Preparation in Visit Clinic

No special preparation is required.

Myeloid Cell Marker : CD 15 Test Parameters in Visit Clinic

The Myeloid Cell Marker : CD 15 test evaluates various parameters. Here are the main parameters checked:

Single test

Why Take a Myeloid Cell Marker : CD 15 Test in Visit Clinic?

Myeloid Cell Marker : CD 15 is often ordered as part of immunophenotyping or lymphoma/leukemia panels when doctors suspect blood cancer or unclear white blood cell problems. It may be requested for symptoms such as abnormal blood counts, persistent infections, unexplained fevers, or swollen lymph nodes. Abnormal results can be caused by malignancy, infection, inflammation, or some medications. A strong family history of blood cancers may make this test more relevant.

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Frequently asked questions

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Is CD15 a myeloid marker in Visit Clinic?

CD15 (Lewis X) is commonly used as a myeloid/granulocyte marker in immunohistochemistry and flow cytometry—strongly expressed on neutrophils, other granulocytes and myeloid precursors. However, it isn’t entirely specific: CD15 can appear on subsets of monocytes, certain B cells and Hodgkin Reed–Sternberg cells. CD15 should be interpreted alongside other markers and morphology for accurate lineage assignment.

What does CD15 positive mean in Visit Clinic?

CD15 positive means cells express the CD15 cell-surface antigen (a carbohydrate/Lewis X–related marker). It’s commonly found on granulocytes and some monocytes and is used in immunohistochemistry to indicate myeloid/granulocytic differentiation. CD15 positivity can support diagnoses such as certain leukemias or classical Hodgkin lymphoma (Reed–Sternberg cells), but it isn’t definitive alone and requires clinical correlation.

What tumors are CD15 positive in Visit Clinic?

CD15 is characteristically positive in classical Hodgkin lymphoma (Reed–Sternberg cells). It is also expressed in myeloid neoplasms (e.g., acute myeloid leukemia with myelomonocytic differentiation) and can be seen in various epithelial malignancies—notably colorectal, gastric, pulmonary (adenocarcinoma), and ovarian carcinomas—and occasionally in other epithelial or urothelial tumors.

What are the CD markers for myeloid cells in Visit Clinic?

Myeloid cells typically express CD11b, CD13, CD14 (monocytes/macrophages), CD33 (myeloid progenitors), CD15 and CD66b (granulocytes/neutrophils), CD16 and CD64 (Fc receptors on neutrophils/monocytes), CD68 (macrophages), and HLA-DR (monocytes/dendritic cells). Early myeloid progenitors may also show CD34 and CD117 (c‑Kit). Marker expression varies with maturation and activation.

Which CD markers indicate leukemia in Visit Clinic?

Leukemia immunophenotypes: B‑cell ALL — CD19, CD10, CD22 (±CD20), CD34, TdT; T‑cell ALL — cytoplasmic/surface CD3, CD2, CD7, CD5, CD1a; AML — myeloid markers CD13, CD33, CD117, CD34, HLA‑DR, with monocytic CD14/CD64; CLL — co‑expression of CD19 with CD5 and CD23 (dim CD20); hairy cell — CD11c, CD25, CD103. CD45 is a pan‑leukocyte marker used in flow cytometry.

What is the function of the CD15 marker in Visit Clinic?

CD15 (Lewis X) is a carbohydrate cell-surface marker expressed on granulocytes, monocytes and some tumor cells. It mediates cell–cell adhesion and recognition, supporting neutrophil rolling, migration, phagocytosis and immune targeting. Clinically, CD15 is used in immunophenotyping to identify granulocytic lineage and aid diagnosis of certain malignancies such as classical Hodgkin lymphoma and some myeloid leukemias.

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