Lab Tests

Megakaryocytic Marker : CD 61

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Megakaryocytic Marker : CD 61, in Visit Clinic

Checks for CD61 protein to identify platelet-producing cells and help diagnose bone marrow or platelet problems in Visit Clinic.

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What is a Megakaryocytic Marker : CD 61 Test in Visit Clinic?

This test detects the CD61 protein, a marker found on platelets and megakaryocytes. Megakaryocytes are the bone marrow cells that make platelets. Platelets are essential for normal blood clotting. Measuring CD61 helps doctors identify and count megakaryocytes in bone marrow samples. It also helps classify types of blood cancers and marrow disorders. The test is often used when blood counts are abnormal, when there is unexplained bleeding or bruising, or when doctors suspect leukemia or myeloproliferative disease. Results are combined with other lab tests and microscope examination to guide diagnosis and treatment decisions.

Megakaryocytic Marker : CD 61 Test Preparation in Visit Clinic

No special preparation is required.

Megakaryocytic Marker : CD 61 Test Parameters in Visit Clinic

The Megakaryocytic Marker : CD 61 test evaluates various parameters. Here are the main parameters checked:

Single test

Why Take a Megakaryocytic Marker : CD 61 Test in Visit Clinic?

Megakaryocytic Marker : CD 61 is usually part of bone marrow immunohistochemistry or leukemia panels used to identify platelet-producing cells. Doctors order it when patients have unexplained low or high platelet counts, unusual bleeding, bruising, or abnormal blood counts. It helps diagnose marrow disorders, myeloproliferative neoplasms, and some leukemias. Abnormal results can come from bone marrow disease, autoimmune destruction, infections, or certain medications. A family history of inherited platelet or marrow disorders makes this marker more relevant.

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Frequently asked questions

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What is CD61 a marker for in Visit Clinic?

CD61 (integrin β3) is a surface marker primarily expressed on platelets and megakaryocytes, used to identify megakaryocytic lineage in blood and bone marrow. It participates in platelet aggregation and thrombus formation. CD61 is also detectable in megakaryoblastic leukemias and platelet-rich thrombi, making it useful diagnostically for platelet lineage identification and assessing platelet-related disorders.

What is the CD marker for megakaryocytes in Visit Clinic?

The principal CD markers for megakaryocytes are CD41 (integrin αIIb) and CD61 (integrin β3), which together form the platelet GPIIb/IIIa complex. Mature megakaryocytes and platelets also express CD42b (GPIbα). CD34 marks progenitors but usually declines with maturation. These markers are routinely used in flow cytometry and immunohistochemistry to identify megakaryocytic lineage.

What disease is seen in megakaryocytes in Visit Clinic?

Abnormal megakaryocytes are seen in myeloproliferative neoplasms—especially essential thrombocythemia and primary myelofibrosis—where they show hyperplasia and atypia. Megakaryocytic dysplasia also occurs in myelodysplastic syndromes, and malignant proliferation defines acute megakaryoblastic leukemia. These conditions cause thrombocytosis, marrow fibrosis or cytopenias and need hematology evaluation with blood counts, bone marrow biopsy, and molecular testing.

Are megakaryocytes CD45 positive in Visit Clinic?

Megakaryocytes generally express the leukocyte common antigen CD45, especially at progenitor stages, but expression often diminishes with maturation; very mature megakaryocytes may be CD45-low or negative. Platelets (anucleate fragments) lack CD45. Thus CD45 is variably present on the megakaryocytic lineage and is not a reliable sole marker of mature megakaryocytes.

Which CD markers indicate leukemia in Visit Clinic?

CD markers used to identify leukemias include: B‑cell ALL—CD19, CD10, CD22 (±CD20); T‑cell ALL—CD3, CD2, CD7; AML—myeloid markers CD13, CD33, CD117 and MPO, often with CD34 in blasts; CLL—co‑expression of CD19 and CD5 with CD23; hairy cell—CD11c, CD25, CD103. Definitive diagnosis requires specialist interpretation with flow cytometry and molecular tests.

What is the name of the CD61 gene in Visit Clinic?

CD61 refers to the gene ITGB3, which encodes the integrin beta-3 subunit. Also known as platelet glycoprotein IIIa (GPIIIa), integrin beta-3 pairs with alpha subunits (commonly alphaIIb) to form receptors involved in platelet aggregation, adhesion, and cell–matrix interactions. Mutations in ITGB3 can cause bleeding disorders such as Glanzmann thrombasthenia.

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