Lab Tests

IRMA (Imatinib Resistance Mutation Analysis) in CML

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IRMA (Imatinib Resistance Mutation Analysis) in CML, in Visit Clinic

Detects mutations in leukemia cells that make the cancer resistant to imatinib, guiding treatment decisions in Visit Clinic.

Centre Visit

₹

SAMPLE TYPE

Blood

FASTING REQUIRED

GENDER

Male/Female

GET REPORTS IN

25 hours

TEST INCLUDED

20K+Customers

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4.5+Rating

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What is a IRMA (Imatinib Resistance Mutation Analysis) in CML Test in Visit Clinic?

IRMA measures genetic mutations in leukemia cells, especially changes in the BCR-ABL gene that cause resistance to imatinib. These mutations change how the drug binds and make treatment less effective. The test is important because it tells doctors whether the current medicine is still working. It helps detect treatment resistance in chronic myeloid leukemia. Doctors use the result to choose a different drug, adjust doses, or consider more intensive options. Testing is done on a blood sample and may be repeated over time. Early detection of resistance helps maintain control of the disease and improve long-term outcomes. Your care team will explain what the results mean for you.

IRMA (Imatinib Resistance Mutation Analysis) in CML Test Preparation in Visit Clinic

No special preparation is required.

IRMA (Imatinib Resistance Mutation Analysis) in CML Test Parameters in Visit Clinic

The IRMA (Imatinib Resistance Mutation Analysis) in CML test evaluates various parameters. Here are the main parameters checked:

Single test

Why Take a IRMA (Imatinib Resistance Mutation Analysis) in CML Test in Visit Clinic?

IRMA (Imatinib Resistance Mutation Analysis) in CML is part of molecular monitoring for patients on imatinib or other TKIs. Doctors order it when blood counts stop improving, symptoms return, or treatment response falls. It detects mutations that cause drug resistance in chronic myeloid leukemia. Abnormal results usually reflect BCR-ABL mutations or disease progression and often lead to changing therapy or closer follow-up.

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Frequently asked questions

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What is the Irma test for CML in Visit Clinic?

There’s no widely recognized "Irma" test for chronic myeloid leukaemia. CML diagnosis and monitoring focus on detecting the BCR‑ABL1 fusion: quantitative PCR (BCR‑ABL1 on the International Scale) for molecular response, cytogenetics/karyotype and FISH, and BCR‑ABL kinase‑domain mutation analysis if resistance is suspected. If you meant a different test name, please clarify.

What is the mechanism of TKI resistance in CML in Visit Clinic?

Tyrosine kinase inhibitor resistance in CML arises mainly from BCR-ABL1 kinase‑domain mutations (e.g., T315I) that impair drug binding, plus BCR-ABL1 amplification or overexpression. Other mechanisms include activation of alternative signaling pathways (SRC, PI3K/AKT, RAS/MAPK), drug efflux or reduced influx, pharmacokinetic issues or nonadherence, and persistence of quiescent leukemic stem cells that evade TKIs.

What is the KD mutation test in Visit Clinic?

Do you mean "KD" as Kawasaki disease, Klinefelter (Klinefelter’s disorder), or something else? "KD" can refer to different conditions. Tell me which KD you mean and I’ll give a 50–75 word explanation.

What is the incidence of T315I mutation in CML patients in Visit Clinic?

T315I occurs in an estimated ~5–10% of all CML patients overall. It represents roughly 15–25% of detected BCR‑ABL kinase‑domain mutations and is more common among patients who develop acquired resistance to tyrosine‑kinase inhibitors. Reported ranges across studies extend to ~5–20% depending on patient population, prior therapy, and testing sensitivity. Genetic testing is routinely used to detect it.

What is the criteria for Irma in Visit Clinic?

Do you mean IRMA as in intra‑retinal microvascular abnormalities in diabetic retinopathy, Hurricane Irma (storm classification/criteria), or something else? Say which one and I’ll reply in 50–75 words based on trusted health sources.

What is the gold standard test for CML in Visit Clinic?

The gold‑standard test for CML is detection of the BCR‑ABL1 (Philadelphia chromosome) fusion. This is traditionally confirmed by cytogenetic karyotyping and by molecular methods; quantitative real‑time RT‑PCR for BCR‑ABL1 is essential for diagnosis confirmation and for sensitive monitoring of treatment response. FISH may be used when karyotyping is not possible.

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