Lab Tests

Hairy Cell Marker : CD 103

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Hairy Cell Marker : CD 103, in Visit Clinic

Measures CD103 marker on blood cells to help detect and track hairy cell leukemia and similar conditions in Visit Clinic.

Centre Visit

₹

SAMPLE TYPE

Blood

FASTING REQUIRED

GENDER

Male/Female

GET REPORTS IN

25 hours

TEST INCLUDED

20K+Customers

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What is a Hairy Cell Marker : CD 103 Test in Visit Clinic?

This test detects the CD103 protein on white blood cells. CD103 is a marker often found on the abnormal B cells in hairy cell leukemia. Measuring CD103 helps doctors recognize and classify specific blood cancers. It is important because hairy cell leukemia needs different treatment than other blood cancers. Doctors use the test as part of a flow cytometry or tissue staining panel. It helps confirm a diagnosis, guide treatment choices, and check for remaining disease after therapy. A positive CD103 result supports the diagnosis of hairy cell leukemia or related disorders. A negative result helps rule out that specific diagnosis but may prompt other tests.

Hairy Cell Marker : CD 103 Test Preparation in Visit Clinic

No special preparation is required.

Hairy Cell Marker : CD 103 Test Parameters in Visit Clinic

The Hairy Cell Marker : CD 103 test evaluates various parameters. Here are the main parameters checked:

Single test

Why Take a Hairy Cell Marker : CD 103 Test in Visit Clinic?

Hairy Cell Marker : CD 103 is usually ordered as part of a leukemia/lymphoma immunophenotyping panel when doctors suspect a blood cancer. It is requested if a patient has low blood counts, enlarged spleen, frequent infections, or abnormal cells on a blood smear. The test helps diagnose hairy cell leukemia, distinguish it from other B‑cell disorders, and monitor treatment response. Abnormal results most often reflect disease, while other illnesses or lab differences can alter findings; a family history of blood cancers may prompt earlier testing.

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Frequently asked questions

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What is CD103 a marker for in Visit Clinic?

CD103 (integrin αE) is commonly used as a marker of tissue-resident lymphocytes—particularly CD8+ tissue-resident memory T (TRM) cells and intraepithelial lymphocytes. It binds E‑cadherin on epithelial cells, helping retain immune cells within mucosal and epithelial tissues. CD103 expression also identifies certain tolerogenic dendritic cell subsets in the gut. High CD103 indicates tissue residency rather than circulating cells.

What are the CD markers for hairy cell leukemia in Visit Clinic?

Hairy cell leukemia characteristically shows a B‑cell phenotype: CD19, CD20, CD22 positive, with strong expression of CD11c, CD25, CD103 and CD123. CD200 is often high. Annexin A1 is typically positive (non‑CD marker). It is usually negative for CD5, CD10 and CD23 on flow cytometry, which helps distinguish it from other B‑cell leukemias.

Is hairy cell leukemia CD20 positive in Visit Clinic?

Yes. Classic hairy cell leukemia typically shows strong, bright CD20 expression on malignant B cells. This immunophenotype aids diagnosis alongside markers like CD11c, CD25 and CD103, and supports use of anti‑CD20 therapy (e.g., rituximab) in selected cases. Variant hairy cell leukemia may have a different marker pattern but usually remains CD20 positive.

What is the triad of hairy cell leukemia in Visit Clinic?

The classic triad of hairy cell leukemia is: (1) splenomegaly, (2) cytopenias—most notably pancytopenia with marked monocytopenia, and (3) the presence of characteristic “hairy” B‑lymphocytes in peripheral blood and bone marrow (often TRAP‑positive and CD25/CD11c/CD103 positive). Diagnosis uses blood smear morphology, immunophenotyping and bone marrow biopsy; splenomegaly may be massive.

Where is CD103 expressed in Visit Clinic?

CD103 (αE integrin) is expressed primarily on intraepithelial lymphocytes and tissue-resident memory CD8+ T cells in mucosal and epithelial tissues (gut, skin, lung), where it binds E‑cadherin. It is also found on a subset of dendritic cells in the intestinal mucosa and on certain mucosal CD4+ Tregs and leukocyte populations involved in local immune surveillance and tolerance.

What is the CD marker for leukemia in Visit Clinic?

CD markers vary by leukemia type. B‑cell ALL typically shows CD19, CD10 and CD20; T‑cell ALL shows CD2, CD3, CD5, CD7. AML commonly expresses myeloid markers CD13, CD33, CD117 and often CD34 in blasts. CLL characteristically has CD19 with aberrant CD5 and CD23 (CD20 dim). CD34 marks hematopoietic stem cells/blasts; flow cytometry is used for diagnosis.

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