First Trimester Quadruple Marker Test

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First Trimester Quadruple Marker Test
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First Trimester Quadruple Marker Test, in Visit Clinic

Measures four pregnancy blood markers to screen for chromosomal conditions and some fetal development problems in Visit Clinic.

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centreCentre Visit
SAMPLE TYPE
Blood
FASTING REQUIRED
No
GENDER
Female
GET REPORTS IN
35 hours
TEST INCLUDED
4
Customers
20K+Customers
Labs
CertifiedLabs
Rating
4.5+Rating
Accuracy
ProvenAccuracy

What is a First Trimester Quadruple Marker Test Test in Visit Clinic?

The First Trimester Quadruple Marker Test measures four pregnancy-related proteins in the mother’s blood: PAPP-A, free beta-hCG, AFP, and inhibin A. These markers come from the placenta and the developing baby and help show how early growth and development are progressing. Abnormal levels can indicate an increased screening risk for chromosomal conditions like Down syndrome or Edwards syndrome. The test can also raise concern for certain neural tube or other developmental problems. Doctors combine these blood results with ultrasound findings and maternal age to calculate a risk score. It is a screening tool, not a diagnosis, so high-risk results usually lead to further testing.

First Trimester Quadruple Marker Test Test Preparation in Visit Clinic

No special preparation is required.

First Trimester Quadruple Marker Test Test Parameters in Visit Clinic

The First Trimester Quadruple Marker Test test evaluates various parameters. Here are the main parameters checked:

  • PAPP-A
  • free beta-hCG
  • AFP
  • inhibin A

Why Take a First Trimester Quadruple Marker Test Test in Visit Clinic?

First Trimester Quadruple Marker Test is a prenatal screening panel often done early in pregnancy alongside ultrasound measurement. It is ordered as part of routine prenatal care, for older maternal age, abnormal ultrasound findings, or family history of chromosomal disorders. The test helps identify increased risk for trisomy 21, trisomy 18, and some neural tube issues. Abnormal results can come from dating errors, multiple pregnancy, maternal weight or medical conditions, medications, or true fetal differences, and typically lead to follow-up testing.

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Frequently asked questions

For any unanswered questions, reach out to our support team via email. We will assist you as soon as possible

What is the cost of quadruple marker test in first trimester in Visit Clinic?plus

The quadruple marker (quad) is a second‑trimester screen (about 15–20 weeks), not a first‑trimester test. Costs vary: it's usually free under public healthcare systems. In private settings, typical ranges are roughly ₹700–₹3,000 in India and about US$50–$250 in the US, though insurance can greatly alter out‑of‑pocket expense. Confirm exact pricing with your provider.

What is the normal range for the quadruple marker test in Visit Clinic?plus

Quad screen results are reported as multiples of the median (MoM). Each analyte is generally considered within the normal range when roughly 0.5–2.0 MoM. Values outside this range may alter risk estimates for chromosomal conditions or neural-tube defects. Interpretation depends on gestational age, maternal factors and lab-specific adjustments; abnormal results usually prompt further diagnostic testing.

When is the best time to do a quadruple marker in Visit Clinic?plus

The best time to do a quadruple marker screen is between 15 and 20 weeks of pregnancy, with optimal accuracy around 16–18 weeks. Accurate gestational dating (usually by early ultrasound) is essential because results depend on precise pregnancy age. Testing before 15 or after 20 weeks reduces reliability; discuss any abnormal results with your clinician for follow-up testing or diagnostic options.

Should I be worried about a positive quadruple marker in Visit Clinic?plus

You shouldn’t panic: a positive quadruple marker indicates increased risk for certain chromosomal conditions or neural tube defects, but it’s a screening test—not diagnostic. Many positives are false alarms. Next steps: confirm dating, get a detailed ultrasound, consider cell‑free DNA (NIPT) for clearer risk assessment, and discuss diagnostic testing (CVS/amniocentesis) and genetic counselling.

Do quad marker tests detect Down syndrome in Visit Clinic?plus

The quad screen measures four maternal blood markers (AFP, hCG, estriol, inhibin A) to estimate a fetus’s risk of Down syndrome. It is a screening test—not diagnostic—so results can be false positive or negative. Performed in the second trimester (about 15–20 weeks), an abnormal screen prompts confirmatory testing such as noninvasive prenatal testing, chorionic villus sampling, or amniocentesis.

What is the next step after a positive quadruple test in Visit Clinic?plus

A positive quadruple screen indicates increased risk, not a diagnosis. Next steps: discuss results with your clinician and a genetic counselor, get a detailed ultrasound, and consider noninvasive prenatal testing (cfDNA) for more accurate risk assessment. Definitive diagnosis requires invasive testing—chorionic villus sampling (first trimester) or amniocentesis (second trimester)—with counseling about benefits and small miscarriage risks.