Lab Tests

CLL Segregation Marker : CD 23

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CLL Segregation Marker : CD 23, in Visit Clinic

Measures CD23 on B cells to help diagnose and distinguish chronic lymphocytic leukemia and guide treatment in Visit Clinic.

Centre Visit

₹

SAMPLE TYPE

Blood

FASTING REQUIRED

GENDER

Male/Female

GET REPORTS IN

25 hours

TEST INCLUDED

20K+Customers

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What is a CLL Segregation Marker : CD 23 Test in Visit Clinic?

This test measures CD23, a protein found on the surface of certain white blood cells called B lymphocytes. CD23 helps regulate immune responses and cell growth. Measuring CD23 is important because its presence or absence helps doctors tell different types of B‑cell cancers apart. It is most often used to help diagnose or monitor chronic lymphocytic leukemia (CLL) and to distinguish CLL from similar conditions. Doctors usually test CD23 as part of a panel called immunophenotyping or flow cytometry. Results guide diagnosis, prognosis, and treatment planning. Repeat testing can monitor how well treatment is working or check for disease recurrence.

CLL Segregation Marker : CD 23 Test Preparation in Visit Clinic

No special preparation is required.

CLL Segregation Marker : CD 23 Test Parameters in Visit Clinic

The CLL Segregation Marker : CD 23 test evaluates various parameters. Here are the main parameters checked:

Single test

Why Take a CLL Segregation Marker : CD 23 Test in Visit Clinic?

CLL Segregation Marker : CD 23 is usually ordered as part of an immunophenotyping panel (flow cytometry) for suspected B‑cell blood cancers. Doctors may request it when a patient has unexplained low or high white blood cell counts, swollen lymph nodes, fatigue, or abnormal blood smear findings. It helps diagnose and monitor chronic lymphocytic leukemia and to tell it apart from other lymphomas. Abnormal results are caused by underlying blood cancers and related bone marrow disorders, not by lifestyle factors. A family history of blood cancers or persistent unexplained lymph node swelling may make this test particularly important.

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Frequently asked questions

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What is CD23 expression in CLL in Visit Clinic?

CD23 is the low‑affinity IgE receptor found on mature B cells. In chronic lymphocytic leukemia (CLL) CD23 is commonly and strongly expressed; coupled with CD5 positivity this immunophenotype helps distinguish CLL from other B‑cell neoplasms (for example, mantle cell lymphoma is usually CD23‑negative). CD23 is assessed by flow cytometry and contributes to diagnosis and disease classification.

What is CD23 a marker for in Visit Clinic?

CD23 (FcεRII) is a low‑affinity IgE receptor expressed mainly on mature and activated B cells, some follicular dendritic cells and monocytes. It serves as a marker of B‑cell activation and differentiation in immunophenotyping. Clinically, CD23 helps distinguish chronic lymphocytic leukemia (typically CD23‑positive) from mantle cell lymphoma (usually CD23‑negative) and is involved in allergic responses.

What CD markers are positive in CLL patients in Visit Clinic?

CLL cells characteristically express B‑cell markers CD19 and CD20 (usually dim) with aberrant T‑cell marker CD5 and CD23 positivity. They typically show weak surface immunoglobulin and CD79b, and are CD43 and CD200 positive; CD22 is often expressed. CD45 is present. Prognostic markers include CD38 and ZAP‑70, which may be positive in subsets.

What tumor cells are positive for CD23 in Visit Clinic?

CD23 is characteristically positive on tumor B cells in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), helping distinguish CLL (CD5+, CD23+) from mantle cell lymphoma (usually CD5+, CD23–). CD23 is also expressed by follicular dendritic cell tumors and can be variably present in some other B‑cell lymphomas. Its pattern aids immunophenotypic diagnosis in hematopathology.

What is CD23 negative in Visit Clinic?

CD23‑negative means a cell lacks surface expression of CD23 (the low‑affinity IgE receptor, FcεRII). In clinical immunophenotyping it indicates absence of this marker on B cells, aiding diagnosis—for example distinguishing mantle cell lymphoma (often CD23‑negative) from chronic lymphocytic leukemia (usually CD23‑positive). It may also reflect altered IgE regulation and B‑cell function.

What is CD33 expression on lymphocytes in Visit Clinic?

CD33 is a myeloid-lineage transmembrane receptor typically expressed on monocytes, granulocytes and myeloid progenitors and is generally absent on normal lymphocytes (B, T, NK). Occasional low or aberrant CD33 expression may be detected on lymphoid blasts in certain leukemias or after activation, but routine immunophenotyping treats lymphocytes as CD33-negative; CD33 positivity usually indicates myeloid lineage.

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