Lab Tests

CD45 / LCA (Leukocyte Common Antigen)

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CD45 / LCA (Leukocyte Common Antigen), in Visit Clinic

Measures CD45 protein to identify white blood cells and distinguish immune-cell tumours from other tissue in Visit Clinic.

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Tissue

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Male/Female

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24 hours

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What is a CD45 / LCA (Leukocyte Common Antigen) Test in Visit Clinic?

This test measures the CD45 protein, also called leukocyte common antigen, which sits on most white blood cells. CD45 helps identify cells that come from the immune system. It is important because it separates immune cells from non-immune tissue under the microscope. Doctors use CD45 staining to detect and classify lymphomas and leukemias. It also helps tell whether a tumour is made of immune cells or has spread from another organ. The test can be done on biopsy tissue or blood by pathologists and lab teams. Results guide diagnosis, treatment choice, and monitoring for disease response or recurrence.

CD45 / LCA (Leukocyte Common Antigen) Test Preparation in Visit Clinic

No special preparation is required.

CD45 / LCA (Leukocyte Common Antigen) Test Parameters in Visit Clinic

The CD45 / LCA (Leukocyte Common Antigen) test evaluates various parameters. Here are the main parameters checked:

Single test

Why Take a CD45 / LCA (Leukocyte Common Antigen) Test in Visit Clinic?

CD45 / LCA (Leukocyte Common Antigen) is often included in immunohistochemistry and flow cytometry panels for suspected blood or lymphoid disease. Doctors may order it when there are swollen lymph nodes, unexplained masses, abnormal blood counts, or suspected lymphoma or leukemia. It helps diagnose and monitor these cancers and distinguish them from metastatic tumours or inflammatory reactions. Abnormal results may come from cancers, infections, or immune disorders, and family history of blood cancers can make testing more important.

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Frequently asked questions

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What is CD45 leukocyte common antigen in Visit Clinic?

CD45 (leukocyte common antigen) is a transmembrane protein tyrosine phosphatase expressed on all nucleated hematopoietic cells. Encoded by PTPRC, it regulates antigen‑receptor signaling in T and B cells by modulating Src family kinases, influencing activation and development. Multiple isoforms (e.g., CD45RA, RO) arise from alternative splicing and serve as differentiation markers in flow cytometry and immunophenotyping.

Is LCA the same as CD45 in Visit Clinic?

Yes. LCA (leukocyte common antigen) is the same as CD45 — a family of transmembrane protein tyrosine phosphatase isoforms expressed on nearly all nucleated hematopoietic (leukocyte) cells. CD45/LCA regulates antigen‑receptor signaling, exists in multiple isoforms, and is widely used as a pan‑leukocyte immunohistochemical marker to identify and classify hematologic cells and lymphoid malignancies.

Is CD45 a marker for lymphoma in Visit Clinic?

CD45 (leukocyte common antigen) is a pan‑leukocyte marker used to identify hematopoietic/lymphoid cells and aids lymphoma diagnosis. Most B‑ and T‑cell lymphomas express CD45, but expression may be reduced or absent in certain entities (for example classical Hodgkin lymphoma Reed–Sternberg cells and some plasma‑cell variants). Flow cytometry and immunohistochemistry use CD45 alongside other markers for accurate classification.

What does it mean when a CD45 marker is positive in Visit Clinic?

A CD45‑positive result means the cells express CD45 (the leukocyte common antigen), indicating they are of hematopoietic/white‑blood‑cell origin. It’s used in flow cytometry and immunohistochemistry to identify and classify leukocytes and to help distinguish lymphoid or myeloid malignancies from non‑hematopoietic tumors. Most leukocytes are CD45+, while mature red cells and platelets lack CD45.

Is CD45 a tumor marker in Visit Clinic?

CD45 is not a general tumor marker. It’s a pan‑leukocyte (leukocyte common antigen) surface protein used to identify hematopoietic cells and distinguish blood‑cell–derived malignancies (leukemias, lymphomas) from non‑hematologic tumors. Some hematologic cancers show altered CD45 expression, so it aids diagnosis and classification, but it is not a tumor‑specific marker for solid tumors or a universal cancer biomarker.

What is a normal CD45 count in Visit Clinic?

CD45 is the pan‑leukocyte marker; a “normal” CD45+ cell count generally mirrors the normal white blood cell count: about 4.0–11.0 × 10^9/L (4,000–11,000/µL). Flow cytometry reports CD45 expression patterns (intensity and percentage) rather than a single universal cutoff; laboratory-specific reference ranges, complete blood count values and clinical context determine whether a result is normal.

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