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CD42a (Megakaryocytic Cell Marker)

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CD42a (Megakaryocytic Cell Marker), in Visit Clinic

Measures a platelet surface marker (CD42a) to identify megakaryocytes and detect platelet or bone marrow problems in Visit Clinic.

Centre Visit

₹

SAMPLE TYPE

Blood

FASTING REQUIRED

GENDER

Male/Female

GET REPORTS IN

25 hours

TEST INCLUDED

20K+Customers

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What is a CD42a (Megakaryocytic Cell Marker) Test in Visit Clinic?

The CD42a test detects a protein found on platelets and their parent cells, megakaryocytes. This protein helps platelets stick and form clots. Measuring CD42a shows whether cells in blood or bone marrow are from the platelet line. Doctors use it when they need to identify platelet-related cells. It helps find causes of low platelet counts, unexplained bleeding, and some bone marrow disorders. The test is often done with flow cytometry or tissue staining. Results guide diagnosis, treatment planning, and monitoring of conditions that affect platelet production or function. It also helps distinguish platelet problems from other blood cell disorders.

CD42a (Megakaryocytic Cell Marker) Test Preparation in Visit Clinic

No special preparation is required.

CD42a (Megakaryocytic Cell Marker) Test Parameters in Visit Clinic

The CD42a (Megakaryocytic Cell Marker) test evaluates various parameters. Here are the main parameters checked:

Single test

Why Take a CD42a (Megakaryocytic Cell Marker) Test in Visit Clinic?

CD42a (Megakaryocytic Cell Marker) is often included in platelet or bone marrow immunophenotyping panels and flow cytometry studies. Doctors may order it for unexplained low platelets, abnormal bleeding, bruising, or when bone marrow disease is suspected. It helps diagnose platelet production problems, immune or inherited platelet disorders, and some blood cancers. Abnormal results can come from bone marrow disease, autoimmune destruction, medications, or toxic exposures. A family history of bleeding or inherited platelet disorders can make this test important.

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Frequently asked questions

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What are the markers for megakaryocytes in Visit Clinic?

Megakaryocyte (MK) markers include platelet glycoproteins: CD41 (GPIIb/IIIa), CD61 (GPIIIa), and the CD42 family (GPIb‑IX‑V, e.g., CD42b). They express thrombopoietin receptor MPL (CD110), von Willebrand factor and platelet factor 4, plus lineage markers like CD36. Key transcription factors are GATA‑1, FOG‑1 and NF‑E2. Mature MKs are CD34‑low/negative; they may also express CD9 and GPVI.

What are the CD markers for Megakaryoblast in Visit Clinic?

Megakaryoblasts typically express platelet-lineage markers CD41 (GPIIb/IIIa) and CD61 (GPIIIa), with CD42 (GPIb complex, e.g., CD42b) appearing as they mature. Early megakaryoblasts often co-express progenitor markers CD34 and CD117 (c‑KIT); CD34 decreases with maturation. CD38 may be positive. They are usually MPO‑negative and show variable CD13/CD33 expression.

What are the CD markers for platelets in Visit Clinic?

Platelets characteristically express CD41 (integrin αIIb), CD61 (integrin β3), CD42a/b/c (GPIX, GPIbα, GPV), and CD36. They are typically CD45– (non‑leukocyte). Activation markers include CD62P (P‑selectin) and CD63; other associated markers used in flow cytometry are CD9, CD31 (PECAM‑1) and CD47.

What is acute myeloid leukemia with megakaryocytic differentiation in Visit Clinic?

Acute myeloid leukemia with megakaryocytic differentiation is an AML subtype in which malignant blasts show platelet‑forming (megakaryocytic) features. Diagnosis requires ≥20% blasts with megakaryocyte markers (CD41, CD61) in bone marrow or blood. It can be de novo or secondary to myelodysplasia/therapy, often causes cytopenias, bleeding and organomegaly, and has variable but often poorer prognosis; treatment may include chemotherapy and stem‑cell transplant.

Are megakaryocytes CD45 positive in Visit Clinic?

Yes. Megakaryocytes are hematopoietic cells that express CD45, though usually at lower intensity than circulating leukocytes (often described as CD45 dim). They characteristically co-express platelet lineage markers (CD41, CD61, CD42) and CD45 levels can vary with maturation and sample preparation — progenitors may show higher CD45 than mature megakaryocytes. Flow cytometry settings affect detection.

What are the bone marrow cell markers in Visit Clinic?

Bone marrow cell markers include hematopoietic stem cell markers (CD34+ CD38− CD90+ CD45RA−), mesenchymal stromal cell markers (CD73+ CD90+ CD105+; negative for CD34, CD45, CD14, CD19, HLA‑DR), and lineage markers: CD45 (pan‑leukocyte); myeloid CD33/CD13; erythroid CD71/CD235a; B cells CD19/CD20; T cells CD3/CD4/CD8; NK cells CD56/CD16. These markers are used clinically and in research to identify, isolate and characterize bone marrow cell populations.

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