Lab Tests

CD22 (Pan B Cell Marker)

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CD22 (Pan B Cell Marker), in Visit Clinic

Measures CD22 on B lymphocytes to help diagnose and monitor B‑cell cancers and immune problems in Visit Clinic.

Centre Visit

₹

SAMPLE TYPE

Blood

FASTING REQUIRED

GENDER

Male/Female

GET REPORTS IN

24 hours

TEST INCLUDED

20K+Customers

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4.5+Rating

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What is a CD22 (Pan B Cell Marker) Test in Visit Clinic?

This test measures the CD22 protein on the surface of B lymphocytes. CD22 is a marker used to identify and count B cells. It helps control B cell activity and the immune response. Measuring CD22 is important for detecting and classifying B‑cell leukemias and lymphomas. It is also used to monitor treatment response and to follow B‑cell recovery after therapy. Doctors use flow cytometry or tissue staining to measure CD22. Results are compared with other markers and clinical findings to reach a diagnosis. The test can influence treatment decisions, including selection of targeted B‑cell therapies. Results are used with other tests and clinical information to guide care.

CD22 (Pan B Cell Marker) Test Preparation in Visit Clinic

No special preparation is required.

CD22 (Pan B Cell Marker) Test Parameters in Visit Clinic

The CD22 (Pan B Cell Marker) test evaluates various parameters. Here are the main parameters checked:

Single test

Why Take a CD22 (Pan B Cell Marker) Test in Visit Clinic?

CD22 (Pan B Cell Marker) is commonly included in flow cytometry and lymphoma/leukemia immunophenotyping panels. Doctors may order it when you have enlarged lymph nodes, unexplained bruising, fatigue, recurring infections, or abnormal blood counts. It helps diagnose and classify B‑cell leukemias and lymphomas and monitor response to therapy. Abnormal results can come from malignancy, immune disorders, infections, or B‑cell–targeting drugs, and a family history of blood cancers may prompt testing.

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Frequently asked questions

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What is CD22 a marker for in Visit Clinic?

CD22 is a B‑cell–specific surface glycoprotein (Siglec‑2) used as a marker of mature B lymphocytes in immunophenotyping. It regulates B‑cell receptor signaling and is present on most mature B cells but usually absent on pro‑B cells and plasma cells. Clinically, CD22 expression helps identify and target B‑cell leukemias and lymphomas.

What are the markers for Pan B cells in Visit Clinic?

Pan-B cell markers include surface and intracellular proteins consistently expressed across B-cell stages: CD19, CD20, CD22, CD79a/CD79b, and PAX5, often with surface immunoglobulin (IgM/IgD) positivity. Additional supportive markers used in diagnostics include CD45 and CD21, while markers like CD10 or CD23 help subtype B-cell populations rather than define the pan‑B lineage.

Which B cells express CD22 in Visit Clinic?

CD22 (Siglec‑2) is a B‑cell–restricted surface lectin expressed mainly on mature B cells — including naïve, memory, follicular and marginal‑zone subsets — from late pre‑B/immature stages onward. Expression is reduced on activated B cells and largely lost on plasmablasts and terminally differentiated plasma cells. It functions in B‑cell signaling and regulation of B‑cell receptor responses.

Is CD20 a pan-B cell marker in Visit Clinic?

No — CD20 is a widely expressed B‑cell antigen present on most mature and many late precursor B cells, making it a common B‑cell marker and therapeutic target. However, it is not truly pan‑B: very early B‑lineage cells (some pro‑B) and terminally differentiated plasmablasts/plasma cells lack CD20, affecting diagnostic staining and response to anti‑CD20 therapies.

Is CD22 expressed on T cells in Visit Clinic?

No — CD22 is a B‑cell–restricted surface lectin (SIGLEC‑2) found on mature B lymphocytes and typically lost during plasma cell differentiation. Normal T cells do not express CD22, so it is not used as a T‑cell marker. Rare aberrant or experimental contexts can show atypical CD22 detection, but physiologically CD22 is absent from conventional T‑cell populations.

What is the full form of CD22 in Visit Clinic?

CD22 stands for Cluster of Differentiation 22. It is a B‑cell–restricted transmembrane sialoglycoprotein (also called Siglec‑2) that acts as an inhibitory coreceptor, modulating B‑cell receptor signaling to help maintain tolerance and regulate activation. CD22 is also exploited as a diagnostic marker and therapeutic target in certain B‑cell malignancies and autoimmune disorders.

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