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CD15 (Myeloid Cell Marker)

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CD15 (Myeloid Cell Marker), in Visit Clinic

Measures CD15 protein on certain immune and tumor cells to help identify myeloid and lymphoma conditions in Visit Clinic.

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What is a CD15 (Myeloid Cell Marker) Test in Visit Clinic?

The CD15 (Myeloid Cell Marker) test detects the CD15 protein on the surface of certain immune cells. CD15 is present on granulocytes and some monocytes. It can also appear on specific tumor cells. This marker helps doctors identify myeloid lineage cells in biopsies and bone marrow. It aids in diagnosing and classifying leukemias, lymphomas, and some tumors. Doctors use CD15 with other markers to guide diagnosis, treatment choice, and monitoring. The test is usually done by staining tissue or marrow samples and reading results with a microscope. Results are interpreted together with clinical findings and other lab tests.

CD15 (Myeloid Cell Marker) Test Preparation in Visit Clinic

No special preparation is required.

CD15 (Myeloid Cell Marker) Test Parameters in Visit Clinic

The CD15 (Myeloid Cell Marker) test evaluates various parameters. Here are the main parameters checked:

Single test

Why Take a CD15 (Myeloid Cell Marker) Test in Visit Clinic?

CD15 (Myeloid Cell Marker) is commonly included on immunohistochemistry and hematopathology panels used to classify blood and lymph node cancers. Doctors may order it when you have abnormal blood counts, swollen lymph nodes, or unexplained infections. It helps diagnose leukemias, lymphomas, and myeloid disorders. Abnormal results reflect changes in cell type or cancer, certain infections, or effects of drugs. A family history of blood cancers may prompt testing.

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Frequently asked questions

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Is CD15 a myeloid marker in Visit Clinic?

Yes — CD15 (Lewis X) is commonly used as a myeloid marker, particularly for granulocytic cells such as neutrophils and eosinophils, and is often positive in myeloid leukemias. However, it is not entirely specific: some monocytes, certain B‑cell subsets, and Hodgkin/Reed–Sternberg cells can also express CD15, so results need correlation with additional markers.

What does CD15 mark in Visit Clinic?

CD15 (Lewis X) is a carbohydrate cell-surface antigen expressed mainly on neutrophils, eosinophils and monocytes, and on some macrophages and epithelial cells. Clinically it marks granulocytic/myeloid differentiation and is used diagnostically—classically positive in Reed–Sternberg cells of classical Hodgkin lymphoma and in subsets of myeloid leukemias. It also participates in cell adhesion and phagocytic responses.

What tumors are CD15 positive in Visit Clinic?

CD15 is expressed by normal granulocytes/monocytes and by several tumors: classically Reed–Sternberg cells in classical Hodgkin lymphoma; many myeloid neoplasms (some acute myeloid and myelomonocytic leukemias); and a subset of epithelial tumors—particularly adenocarcinomas (colorectal, gastric, pulmonary and others). Occasional non‑Hodgkin lymphomas and reactive inflammatory cells can also be CD15‑positive. It’s used diagnostically in immunohistochemistry.

What are the CD markers for myeloid cells in Visit Clinic?

Myeloid cells typically express CD11b, CD13 and CD33 as core myeloid markers. Monocytes/macrophages show CD14, CD64 and CD68; neutrophils/granulocytes express CD15, CD16 and CD66b. Antigen‑presenting myeloid dendritic cells express HLA‑DR and subsets show CD1c or CD123. CD117 (c‑Kit), CD34 and Fc receptors like CD32 mark progenitors and functional myeloid subsets.

Which CD markers indicate leukemia in Visit Clinic?

Leukemia immunophenotyping uses CD markers: B‑lineage ALL—CD19, CD10, CD22, CD20; T‑ALL—CD2, CD3, CD5, CD7, CD1a; AML—myeloid markers CD13, CD33, CD117 and MPO, often CD34 on blasts; chronic lymphocytic leukemia—CD19 with aberrant CD5 and CD23 (weak surface Ig); monocytic leukemias show CD14 and CD64. CD45 is used for leukocyte gating. Flow cytometry confirms diagnosis.

Is CD15 positive in eosinophils in Visit Clinic?

No — CD15 (Lewis X) is not typically positive on eosinophils. CD15 is a myeloid/neutrophil-associated antigen used to identify neutrophils and some monocytes. Eosinophils characteristically express different markers (for example IL‑5Rα/CD125, Siglec‑8, CCR3). Occasional reports note weak or variable CD15 staining, but CD15 is not a reliable eosinophil marker.

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