CD123 (Monocytic Macrophage Marker)

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CD123 (Monocytic Macrophage Marker)
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CD123 (Monocytic Macrophage Marker), in Visit Clinic

Measures CD123 protein on blood cells to help identify certain immune cells and diagnose blood cancers in Visit Clinic.

centreCentre Visit
SAMPLE TYPE
Blood
FASTING REQUIRED
No
GENDER
Male/Female
GET REPORTS IN
26 hours
TEST INCLUDED
1
Customers
20K+Customers
Labs
CertifiedLabs
Rating
4.5+Rating
Accuracy
ProvenAccuracy

What is a CD123 (Monocytic Macrophage Marker) Test in Visit Clinic?

This test measures the CD123 protein on the surface of certain white blood cells. CD123 is part of the receptor for a growth signal called interleukin-3. Detecting CD123 helps lab doctors identify and classify specific immune and myeloid cells. It is important for diagnosing and monitoring some blood cancers, such as acute myeloid leukemia and blastic plasmacytoid dendritic cell neoplasm. Doctors use it with flow cytometry to guide diagnosis, follow treatment response, and sometimes to choose targeted therapies that act on CD123-positive cells.

CD123 (Monocytic Macrophage Marker) Test Preparation in Visit Clinic

No special preparation is required.

CD123 (Monocytic Macrophage Marker) Test Parameters in Visit Clinic

The CD123 (Monocytic Macrophage Marker) test evaluates various parameters. Here are the main parameters checked:

  • Single test

Why Take a CD123 (Monocytic Macrophage Marker) Test in Visit Clinic?

CD123 (Monocytic Macrophage Marker) is commonly included in flow cytometry panels for suspected blood cancers and marrow disorders. Doctors may order it when someone has unexplained bruising, low blood counts, frequent infections, or abnormal blood smears. The test helps diagnose and monitor leukemias and related conditions, and guides targeted treatment choices. Abnormal results most often reflect cancerous cell populations, but inflammation or certain medications can affect expression; family history of blood cancers may increase the test’s relevance.

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Frequently asked questions

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What is CD123 a marker for in Visit Clinic?plus

CD123 is the alpha chain of the interleukin‑3 receptor and serves as a cell‑surface marker for plasmacytoid dendritic cells. It is also highly expressed on malignant cells in hematologic cancers—notably acute myeloid leukemia blasts, leukemic stem cells, and blastic plasmacytoid dendritic cell neoplasm—making it useful diagnostically and as a therapeutic target.

Are monocytes CD123 positive in Visit Clinic?plus

Monocytes are generally CD123 negative; they characteristically express CD14, CD16, CD11b and HLA‑DR. CD123 (the IL‑3 receptor α chain) is typically found on plasmacytoid dendritic cells, basophils and certain hematologic malignancies. Rarely, activated or atypical monocyte subsets may show low-level CD123 expression in specific pathological contexts, but CD123 is not a conventional monocyte marker.

Do macrophages express CD123 in Visit Clinic?plus

No. Mature macrophages generally do not express CD123 (IL‑3Rα) at appreciable levels. CD123 is classically a marker of plasmacytoid dendritic cells, basophils and certain hematopoietic progenitors. Inflammatory signals can induce transient IL‑3Rα expression on monocytes or precursors, but constitutive CD123 on differentiated tissue macrophages is minimal. Therefore CD123 is not a reliable macrophage marker for diagnostics or flow cytometry.

What is CD123 expression on T cells in Visit Clinic?plus

CD123 is the alpha chain of the interleukin‑3 receptor. It is normally expressed on plasmacytoid dendritic cells, basophils and some myeloid blasts; healthy peripheral T cells usually have little or no CD123. Detectable CD123 on T cells often indicates activation or aberrant/leukemic expression and can be used diagnostically or as a therapeutic target in certain blood cancers.

Which CD markers indicate leukemia in Visit Clinic?plus

Common CD markers used to identify leukemia subtypes: B‑cell ALL—CD19, CD10, CD22, CD20; T‑cell ALL—CD2, CD3, CD5, CD7 (±CD1a, CD4/CD8); AML—myeloid markers CD13, CD33, CD117 and stem/progenitor CD34 (MPO/HLA‑DR patterns help); CLL—coexpression of CD19, CD5 and CD23 (dim CD20); hairy cell leukemia—CD11c, CD25, CD103. Immunophenotyping by flow cytometry determines diagnosis and guides treatment decisions.

Do eosinophils express CD123 in Visit Clinic?plus

Yes. Human eosinophils express CD123 (the IL‑3 receptor α chain), typically at low-to-moderate levels compared with plasmacytoid dendritic cells or basophils. CD123 on eosinophils is functional—eosinophils respond to IL‑3 alongside IL‑5 and GM‑CSF via shared signaling, but IL‑5 receptor α (CD125) is the more characteristic, highly expressed eosinophil marker. Levels vary with activation state.