Anti Deamidated Gliadin Peptide - IgA, in Visit Clinic

High deamidated gliadin IgA indicates an immune reaction to specific gluten peptides and suggests possible celiac disease. It’s more specific than older gliadin tests but not diagnostic alone. Recommended next steps: check total IgA, get tissue transglutaminase (tTG) IgA testing and often a gastroenterology referral for confirmatory duodenal biopsy before starting a gluten‑free diet. False positives or IgA deficiency can alter results.

Normal (negative) deamidated gliadin peptide (DGP) IgA is lab-dependent but commonly reported as below the assay cutoff—often <20 U/mL (some labs use <7–10 U/mL). Results in an equivocal range (frequently ~20–30 U/mL) are indeterminate; values above the lab cutoff are considered positive and warrant further evaluation (e.g., tTG IgA testing and clinical correlation).

The anti-gliadin IgA test detects IgA antibodies against gliadin, a component of gluten. It was historically used to screen for celiac disease or other gluten-related immune responses but is less specific than tissue transglutaminase (tTG) or endomysial antibody tests. Elevated levels suggest immune reaction to gluten or gut damage; total IgA should be checked because IgA deficiency can cause false negatives.

Yes—most people with celiac disease have positive IgA‑based antibodies, especially tissue transglutaminase IgA (tTG‑IgA) and endomysial IgA (EMA). A positive IgA serology strongly suggests celiac disease, but diagnosis often requires confirmatory intestinal biopsy or specialist assessment. Because selective IgA deficiency can cause false negatives, labs also measure total IgA and may use IgG‑based tests if IgA is low.

No — celiac disease is an autoimmune condition that does not go away. A strict lifelong gluten-free diet usually resolves symptoms and allows intestinal healing, but the underlying intolerance to gluten remains. Reintroducing gluten causes relapse; some people develop refractory disease requiring specialist treatment. Regular follow-up and dietary vigilance are essential to prevent complications.

Concern arises when serum IgA falls below the laboratory’s lower reference (typically about 70 mg/dL in adults); selective IgA deficiency is defined as <7 mg/dL (0.07 g/L) with normal IgG and IgM. Marked elevations (often >400 mg/dL) may indicate infection, liver disease, autoimmune conditions, or monoclonal gammopathy. Interpret results with symptoms and other immunoglobulin levels; consult your clinician.