Pyridoxine (vitamin B6) supports amino acid and neurotransmitter metabolism, hemoglobin synthesis and immune function. Clinically it treats or prevents B6 deficiency symptoms (skin changes, glossitis, neuropathy, microcytic or sideroblastic anemia), helps lower homocysteine, and is used to prevent isoniazid‑induced neuropathy and to manage nausea and vomiting in pregnancy (often combined with doxylamine).

Vitamin B6 (pyridoxine) supports protein, carbohydrate and fat metabolism and helps convert food into energy. It’s essential for neurotransmitter synthesis (serotonin, dopamine), normal brain function and mood regulation, and for hemoglobin formation and healthy immune responses. Adequate B6 may ease pregnancy-related nausea and some PMS symptoms; it also helps lower homocysteine with B12/folate, supporting heart health.

People with pre-existing peripheral neuropathy, those taking levodopa without carbidopa, and anyone allergic to pyridoxine should avoid vitamin B6 supplements unless advised by a clinician. High-dose pyridoxine (often >100 mg/day) can cause sensory nerve damage and should be avoided. Also consult your healthcare provider before taking B6 if pregnant, breastfeeding, or if you have liver/kidney disease or take other medications.

Vitamin B6 (pyridoxine) can reduce nausea and vomiting in pregnancy and is commonly recommended as a first-line treatment. Typical doses are 10–25 mg taken three times daily; combining it with doxylamine is often more effective. It’s generally considered safe, but speak with your healthcare provider before starting to confirm the correct dose and rule out other causes.

Vitamin B6 deficiency can cause anemia (often microcytic), peripheral neuropathy with numbness and tingling, and skin changes such as seborrheic dermatitis, cheilosis and a sore, swollen tongue. Other signs include irritability, depression, confusion, weakened immune responses and, in severe cases, seizures or cognitive decline. Symptoms often develop gradually and are more likely with poor diet, alcoholism, certain drugs or malabsorption.

Fruits high in vitamin B6 include bananas and avocados (notably), melons like cantaloupe and watermelon, tropicals such as mango and papaya, and many dried fruits — prunes, raisins and apricots. Kiwi and pineapple also provide B6. Including a mix of fresh and dried fruits and varying portions can help meet daily vitamin B6 needs.