Rapid Plasma Reagin (RPR Test)

The RPR (rapid plasma reagin) is a blood screening test for syphilis that detects non-treponemal antibodies produced against tissue damage. It’s used for initial screening and monitoring treatment response via quantitative titers. Results can be false-positive in other infections, autoimmune conditions, or pregnancy, so reactive RPR tests require confirmation with a treponemal-specific test.

A positive RPR suggests possible syphilis but can be falsely positive. It leads to confirmatory treponemal testing (e.g., TP‑PA/FTA‑ABS), clinical assessment and screening for other STIs including HIV, plus partner notification. If confirmed, treatment is usually intramuscular benzathine penicillin with follow‑up RPR titers to document response; additional management depends on disease stage and pregnancy status.

The RPR (Rapid Plasma Reagin) is a non-treponemal blood test that screens for syphilis by detecting antibodies to cardiolipin. A blood sample is tested on a rapid card or laboratory assay; trained personnel assess reactivity (flocculation) and report results. Reactive tests require confirmation with a treponemal-specific assay and clinical evaluation. Discuss results and treatment with a healthcare professional.

In India, an RPR (rapid plasma reagin) syphilis screening test typically costs between ₹200 and ₹800 at private diagnostic labs; prices may be lower at government hospitals or free at public health centres. Costs vary by city, lab reputation, and whether it’s bundled with other tests. Confirm exact pricing with your local diagnostic centre before testing.

The RPR (Rapid Plasma Reagin) test does not require fasting. It’s a routine blood test with no special dietary preparation. Inform your provider about recent infections, vaccinations, pregnancy, autoimmune conditions, or antibiotic use, as these can affect results. Follow any specific instructions given by your clinic, but fasting is generally unnecessary.

Syphilis can range from a painless sore in early stages to life‑threatening disease if untreated. It progresses through primary, secondary, latent and tertiary stages, potentially causing neurological problems (neurosyphilis), heart disease, blindness, dementia, and death. Congenital syphilis can cause miscarriage, stillbirth, or severe infant disability. It is curable—especially with early penicillin—so prompt testing and treatment are essential.