Question 1

What is a RA factor quantitative test?

Accepted Answer

A rheumatoid factor (RF) quantitative test measures the level of RF antibodies in blood—usually IgM—that are associated with rheumatoid arthritis. It helps diagnose and monitor disease activity; higher titers often correlate with more severe or persistent disease. A positive result supports but does not confirm RA, since RF can appear in other autoimmune or infectious conditions. Results are interpreted alongside clinical findings and other tests (e.g., anti‑CCP, CRP).

Question 2

What is a normal rheumatoid factor level in a child?

Accepted Answer

A normal rheumatoid factor (RF) in children is generally negative or very low. Most laboratory reference ranges consider an RF below about 14–20 IU/mL (commonly <15 IU/mL) as normal. Positive or higher values require clinical correlation and further evaluation, since ranges vary by lab and RF can be absent even in juvenile arthritis. Discuss results with a pediatrician or pediatric rheumatologist.

Question 3

What is the cost of a RA factor test?

Accepted Answer

Costs vary: in the US typically $20–$150 out‑of‑pocket (often covered by insurance); in India about ₹200–₹800 at private labs; in the UK it’s usually free under the NHS or £20–£50 privately; Australia is often bulk‑billed or A$20–A$50 privately. Prices depend on lab, test panel, and whether insured or publicly funded—check your local provider.

Question 4

What is a rheumatoid factor blood test for a child?

Accepted Answer

A rheumatoid factor (RF) blood test detects antibodies that can indicate autoimmune joint disease. In children it helps support diagnosis of certain arthritis types (for example RF‑positive juvenile idiopathic arthritis) but is neither sensitive nor specific alone. Results are interpreted with symptoms, exam, imaging and other labs (ESR, CRP, anti‑CCP). The test is a simple blood draw; no special preparation is usually needed.

Question 5

What cancers have high rheumatoid factor?

Accepted Answer

Elevated rheumatoid factor is most often seen with B‑cell and lymphoproliferative malignancies—especially non‑Hodgkin and Hodgkin lymphoma, chronic lymphocytic leukemia, Waldenström macroglobulinemia and multiple myeloma. RF can also be mildly raised in some solid tumors (lung, breast, pancreatic, liver) and with paraneoplastic immune responses, though less commonly than with hematologic cancers. Clinical context and further testing determine significance.

Question 6

What are the early symptoms of rheumatoid arthritis?

Accepted Answer

Early rheumatoid arthritis often causes joint pain, swelling, warmth and tenderness—typically symmetrically affecting small joints of the hands and feet. Morning stiffness lasting 30–60 minutes, reduced grip strength, and difficulty using affected joints are common. Systemic signs include persistent fatigue, low‑grade fever, loss of appetite and general malaise. Symptoms may be subtle at first and come and go.

Question 7

What is HLA Cw6 associated with?

Accepted Answer

HLA‑Cw6 is a genetic marker strongly associated with psoriasis, particularly early‑onset (type I) and guttate forms. It’s linked to family history and streptococcal‑triggered flares, tends to associate with specific clinical patterns (scalp and widespread lesions) and earlier onset, and can affect disease course. Presence of HLA‑Cw6 may also influence prognosis and response to some therapies.

Question 8

What is the HLA marker for Behcet's disease?

Accepted Answer

The major HLA marker associated with Behçet’s disease is HLA‑B51 (part of the HLA‑B5 serotype). HLA‑B51 increases susceptibility, especially in Mediterranean, Middle Eastern and East Asian populations, but it is not diagnostic alone. Many affected individuals do not carry the marker, and many carriers never develop disease; clinical evaluation and other tests are required.

Question 9

Which HLA is associated with psoriatic arthritis?

Accepted Answer

HLA-B27 is the HLA allele most commonly associated with psoriatic arthritis, particularly with axial involvement and sacroiliitis. Its presence increases the likelihood of spinal and joint inflammation and can influence disease pattern and prognosis. Other HLA class I alleles (for example HLA-B38 and B39) may also be implicated, but HLA-B27 is the principal genetic marker linked to psoriatic arthritis.

Question 10

Which HLA is associated with lupus?

Accepted Answer

Systemic lupus erythematosus is most strongly associated with HLA class II alleles, particularly HLA-DR2 and HLA-DR3 (notably DRB1*15:01 and DRB1*03:01). These alleles correlate with higher susceptibility and autoantibody production, though associations vary by ethnicity and presence of these HLAs does not guarantee disease—genetic and environmental factors together determine risk. Testing may inform risk assessment in select cases.

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