Dihydrotestosterone (DHT)

Dihydrotestosterone (DHT) is a potent androgen formed from testosterone by 5α‑reductase. It binds androgen receptors to drive male fetal genital development and pubertal changes such as facial/body hair, voice deepening and prostate growth. In adults DHT supports libido and sexual function but can also contribute to male-pattern hair loss (androgenic alopecia) and benign prostatic enlargement.

DHT rises when testosterone is converted to dihydrotestosterone by the 5α‑reductase enzyme. Factors that increase DHT include higher testosterone levels, increased 5α‑reductase activity or gene variants, genetic androgen sensitivity, puberty, anabolic steroid use, endocrine conditions (e.g., PCOS or adrenal disorders), obesity/insulin resistance, and some medications or supplements that alter hormone metabolism.

Lower DHT by using prescription 5‑alpha‑reductase inhibitors (finasteride or dutasteride) under medical supervision; topical options like ketoconazole shampoo or topical finasteride can reduce scalp DHT. Lifestyle: lose weight, improve insulin sensitivity, exercise, cut high‑sugar intake and avoid anabolic steroids. Some supplements (saw palmetto, pumpkin seed oil) show limited benefit. Discuss risks and monitoring with your clinician.

Yes, sometimes. Hair loss from DHT (androgenetic alopecia) can be slowed or partially reversed if hair follicles remain viable. Treatments that lower DHT (oral finasteride) or stimulate follicles (topical minoxidil, low‑level laser therapy, hair transplant) often produce regrowth within months, but results vary. Long‑standing, permanently damaged follicles won’t recover, and effective treatments usually require ongoing use and medical supervision.

High DHT can be both beneficial and harmful. It’s vital for male sexual development, secondary sex characteristics and libido, but excess DHT is linked to male-pattern baldness, benign prostatic hyperplasia and prostate disease, acne, and in women can cause hirsutism and menstrual irregularities. If symptoms suggest high DHT, consult a clinician — testing and treatments (e.g., 5‑alpha‑reductase inhibitors and lifestyle measures) can help.

Regular exercise doesn’t reliably lower DHT directly. Short bouts of resistance training can briefly raise testosterone and DHT, while long-term aerobic activity, weight loss and improved insulin sensitivity may modestly reduce androgen activity and inflammation that worsen DHT-related conditions. For significant DHT reduction (e.g., treating hair loss or prostate issues), medications like 5‑alpha‑reductase inhibitors are typically required; discuss options with your clinician.