CMV PCR Quantitative

A positive CMV PCR indicates detection of cytomegalovirus DNA in the tested sample, showing active viral replication rather than just past exposure. It may reflect primary infection, reactivation, or reinfection. Clinical context (pregnancy, newborn, or immunocompromised host) and viral load guide management: observation, antiviral therapy, or further testing to assess disease severity and need for treatment.

CMV qualitative PCR is a laboratory test that detects whether cytomegalovirus (CMV) DNA is present in blood, tissue, or other bodily fluids. It confirms the presence or absence of active CMV infection but does not measure viral amount. It’s used to diagnose infection—especially in pregnant people and immunocompromised patients—and guides further testing or treatment; a positive result means CMV DNA was detected.

Cost varies by country and lab: in India roughly ₹2,000–6,000; in the US about $100–500 (depending on hospital vs outpatient lab); in the UK privately around £50–200. Public/NHS or insurance-covered tests may be free or billed differently. Prices fluctuate by testing method, turnaround time and local facility—check with the specific lab or insurer for exact pricing.

Most people who are CMV-positive have no symptoms or only mild flu‑like illness. CMV can cause severe disease in newborns (congenital CMV—risk of hearing loss and developmental delay) and in immunocompromised people (pneumonitis, retinitis). Diagnosis uses blood tests or PCR. Healthy adults usually need no treatment; antivirals (ganciclovir/valganciclovir) are used for severe or congenital infections. Hygiene and prenatal screening help prevention.

If CMV PCR is positive, management depends on symptoms and immune status. Asymptomatic immunocompetent patients often need observation and repeat PCR. Symptomatic or immunocompromised patients require antiviral therapy—typically IV ganciclovir or oral valganciclovir—with reduction of immunosuppression if possible. Monitor viral load, organ function (e.g., retina, marrow), treat complications, consider resistance testing and specialist input.

A positive PCR test means the test detected the virus’s genetic material, indicating current or very recent infection. It does not directly measure how contagious you are or how severe illness will be; PCR can sometimes detect non‑infectious remnants after recovery. Follow public‑health guidance: isolate as advised, notify close contacts, seek medical advice for worsening symptoms, and consider retesting according to local guidelines.