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CD34 (Precursor Cell Marker)

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CD34 (Precursor Cell Marker)
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CD34 (Precursor Cell Marker)

Measures CD34-positive precursor cells to check bone marrow stem cell levels and transplant readiness.

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SAMPLE TYPE
Blood
FASTING REQUIRED
No
GENDER
Male/Female
GET REPORTS IN
24 hours
TEST INCLUDED
1
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20K+Customers
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CertifiedLabs
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4.5+Rating
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ProvenAccuracy

What is a CD34 (Precursor Cell Marker) Test?

The CD34 (Precursor Cell Marker) test measures the number of CD34-positive cells in the blood or bone marrow. These CD34 cells are hematopoietic stem and progenitor cells that make all types of blood cells. They are essential for healthy blood production and for bone marrow recovery after treatment. The test helps doctors decide when stem cell collection is sufficient for transplant. It also helps diagnose or monitor blood cancers and bone marrow disorders. Doctors use CD34 counts to guide stem cell mobilization, timing of collection, and to follow recovery after transplant or chemotherapy. Results can show low stem cell reserves or high numbers in certain leukemias.

CD34 (Precursor Cell Marker) Test Preparation

No special preparation is required.

CD34 (Precursor Cell Marker) Test Parameters

The CD34 (Precursor Cell Marker) test evaluates various parameters related to the different components. Here are the main parameters that are checked in the test:

  • Single test

Why Take a CD34 (Precursor Cell Marker) Test?

CD34 (Precursor Cell Marker) is often included in hematology and transplant evaluation panels. It is ordered when blood counts are abnormal or when stem cell transplant is being planned. The test helps diagnose and monitor leukemia, bone marrow failure, and response to treatment. Abnormal results can be caused by marrow disease, chemotherapy, growth factor drugs, or mobilization therapy. A family history of bone marrow disorders may make this test more important.

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Frequently asked questions

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What cells are CD34 marker for?plus

CD34 is a cell surface glycoprotein marker chiefly expressed on hematopoietic stem and progenitor cells, including those in bone marrow and umbilical cord blood. It also marks endothelial and endothelial progenitor cells, certain vascular-associated cells, and some dendritic cell subsets. Clinically, CD34 is used to identify, isolate, and quantify stem/progenitor cells for transplantation and research.

What does positive CD34 mean?plus

CD34 positive means cells express the CD34 surface antigen, marking hematopoietic stem and progenitor cells and some endothelial cells. Detection by flow cytometry or immunohistochemistry indicates cellular immaturity or stem-cell characteristics, used to diagnose certain leukemias, quantify stem-cell collections for transplant, and isolate progenitor cells. CD34 status can inform prognosis and treatment choices depending on the clinical context.

What is CD150 a marker for?plus

CD150 (SLAMF1) is a cell-surface receptor used as a marker to identify and isolate hematopoietic stem cells—especially long-term HSCs in research—while also being expressed on activated immune cells (T and B lymphocytes, macrophages, dendritic cells). It participates in immune cell activation and signaling and can act as a receptor for measles virus.

What is CD34-positive and negative?plus

CD34-positive cells express the CD34 surface protein—mainly hematopoietic stem/progenitor cells and some endothelial progenitors—used to identify and quantify stem cells for transplantation and recovery monitoring. CD34-negative cells lack this marker, representing more differentiated blood cells and many non-hematopoietic cell types. Clinically, CD34 testing guides stem cell collection, transplant decisions, and certain hematology diagnostics.

Does everyone have CD34 positive cells?plus

Almost everyone carries CD34‑positive cells: they are markers on hematopoietic stem/progenitor cells (mainly in bone marrow), endothelial progenitors and some tissue progenitors. Peripheral blood levels are normally low but rise with age, illness, or after mobilizing treatments. Rare conditions (severe bone marrow failure or certain therapies) can markedly reduce or nearly eliminate detectable CD34+ cells.

What is another name for CD34?plus

Another name for CD34 is the hematopoietic progenitor cell antigen (HPCA‑1). CD34 is a transmembrane sialomucin‑like glycoprotein expressed on early haematopoietic and endothelial progenitor cells; it’s often referred to as the CD34 antigen or haematopoietic stem/progenitor cell marker used to identify and isolate stem cells in clinical and research settings.

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