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CD11c (Hairy Cell / NHL Marker)

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CD11c (Hairy Cell / NHL Marker)

Measures CD11c protein on white blood cells to help diagnose and monitor certain leukemias and lymphomas.

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SAMPLE TYPE

Blood

FASTING REQUIRED

GENDER

Male/Female

GET REPORTS IN

24 hours

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What is a CD11c (Hairy Cell / NHL Marker) Test ?

This test measures the CD11c protein on the surface of certain white blood cells. CD11c helps identify specific immune cell types and is useful when blood or bone marrow looks abnormal. It is important because its presence or pattern helps doctors tell different kinds of blood cancers apart. The test is commonly used to detect or monitor hairy cell leukemia and some non-Hodgkin lymphomas. Doctors use it as part of an immunophenotyping panel to confirm a diagnosis, plan treatment, and check how well therapy is working. Results are reported alongside other markers and blood counts to give a full picture.

CD11c (Hairy Cell / NHL Marker) Test Preparation

No special preparation is required.

CD11c (Hairy Cell / NHL Marker) Test Parameters

The CD11c (Hairy Cell / NHL Marker) test evaluates various parameters. Here are the main parameters checked:

Single test

Why Take a CD11c (Hairy Cell / NHL Marker) Test ?

CD11c (Hairy Cell / NHL Marker) is usually run as part of a flow cytometry immunophenotyping panel for suspected blood cancers. A doctor may order it when blood counts are abnormal, when you have unexplained fatigue, bruising, infections, or an enlarged spleen. It helps diagnose hairy cell leukemia and some non-Hodgkin lymphomas and guides treatment choices. Abnormal results most often reflect disease in the bone marrow or blood, and a family history of blood cancers can make this testing more important.

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Frequently asked questions

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What are the CD markers for hairy cell lymphoma?

Hairy cell lymphoma/leukemia characteristically expresses B‑cell markers CD19, CD20 and CD22, plus the classic HCL markers CD11c, CD25, CD103 and CD123. Cells are typically bright for CD45 and surface immunoglobulin. They are usually negative for CD5 and CD10. Ancillary markers like annexin A1 and TRAP activity support the diagnosis but are not CD antigens.

What are the biomarkers for hairy cell leukemia?

Biomarkers for hairy cell leukemia include an immunophenotype expressing B‑cell markers (CD19, CD20) plus strong CD11c, CD25, CD103 and CD123 positivity; annexin A1 and TRAP (tartrate‑resistant acid phosphatase) are characteristic. Most classic cases harbor the BRAF V600E mutation. Laboratory features often show monocytopenia and pancytopenia with splenomegaly supporting diagnosis.

What is the confirmatory test for hairy cell leukemia?

The confirmatory test for hairy cell leukemia is a bone marrow biopsy with immunophenotyping by flow cytometry showing characteristic B cells positive for CD11c, CD25, CD103 and CD123. Tartrate‑resistant acid phosphatase (TRAP) staining can be supportive. Molecular detection of the BRAF V600E mutation further confirms classic hairy cell leukemia and informs treatment decisions.

What is the triad of hairy cell leukemia?

The triad of hairy cell leukemia is massive splenomegaly, peripheral cytopenias (especially neutropenia with marked monocytopenia), and circulating “hairy” B lymphocytes on peripheral smear and bone marrow. These cells are typically tartrate‑resistant acid phosphatase–positive and show a characteristic immunophenotype (CD11c, CD25, CD103), which helps confirm the diagnosis. Clinical features often include fatigue, infections, and left upper‑quadrant discomfort.

What CD markers indicate lymphoma?

CD markers used to diagnose lymphoma include B‑cell markers CD19, CD20, CD22 and CD79a; germinal‑center marker CD10; mantle‑cell often shows CD5 with cyclin D1 overexpression; chronic lymphocytic leukemia/small‑cell lymphoma shows CD5 and CD23 co‑expression. T‑cell markers include CD2, CD3, CD5 and CD7. Classical Hodgkin/Reed‑Sternberg cells typically express CD30 and often CD15.

Is hairy cell leukemia a type of NHL?

Yes. Hairy cell leukemia is a rare, indolent B‑cell malignancy classified within the non‑Hodgkin lymphomas. It arises from mature B lymphocytes, causes bone marrow infiltration, splenomegaly and cytopenias, and is considered a distinct chronic B‑cell lymphoproliferative disorder. Diagnosis uses blood/marrow immunophenotyping; treatment typically involves purine‑analog chemotherapy and targeted agents.

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A big thank you to Shikhar from the Visit app for going above and beyond to arrange a last-minute appointment during an urgent situation. His seamless coordination truly made a difference.

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