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CD34 Viable Cells

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CD34 Viable Cells
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CD34 Viable Cells

Measures the number of live CD34-positive stem cells in blood or grafts to assess transplant readiness.

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SAMPLE TYPE
Blood
FASTING REQUIRED
No
GENDER
Male/Female
GET REPORTS IN
25 hours
TEST INCLUDED
1
customers
20K+Customers
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CertifiedLabs
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4.5+Rating
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ProvenAccuracy

What is a CD34 Viable Cells Test?

CD34 Viable Cells measures the number of living CD34-positive stem and progenitor cells in a blood sample or graft. These early blood-forming cells are needed to rebuild the bone marrow after chemotherapy or transplant. The test helps doctors know if a collected sample has enough cells for a successful transplant. It also shows how well the marrow responded to mobilizing drugs. Low counts may indicate poor mobilization, prior chemotherapy damage, or marrow failure. Results help decide timing of collection, need for more procedures, or alternative treatments to improve transplant success.

CD34 Viable Cells Test Preparation

No special preparation is required.

CD34 Viable Cells Test Parameters

The CD34 Viable Cells test evaluates various parameters related to the different components. Here are the main parameters that are checked in the test:

  • Single test

Why Take a CD34 Viable Cells Test?

CD34 Viable Cells is usually included in stem cell collection and transplant panels. Doctors order it when planning bone marrow or peripheral blood stem cell transplantation, after mobilization therapy, or when low blood counts cause infections or fatigue. It helps diagnose poor mobilization or marrow failure and monitor graft quality. Abnormal results can follow prior chemotherapy, radiation, certain medicines, or inherited marrow disorders. Family history of marrow disease may prompt testing.

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Frequently asked questions

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What do CD34 positive cells mean?plus

CD34-positive (CD34+) cells carry the CD34 protein on their surface and are primarily hematopoietic stem and progenitor cells, plus some endothelial progenitors. Detecting CD34+ cells shows presence and quantity of cells that can regenerate blood and immune cells, important for stem cell transplants, graft evaluation and monitoring stem cell mobilization. CD34 expression varies; functional capacity is assessed alongside counts.

What is stem cell viability?plus

Stem cell viability refers to the proportion of living, functional stem cells in a sample—cells able to survive, proliferate and differentiate. It’s measured by membrane integrity, metabolic activity and colony-forming ability. High viability is essential for reliable research, transplantation and regenerative therapies, and depends on donor factors, isolation methods, handling, storage and cryopreservation protocols.

What is a good CD34 count?plus

A "good" CD34 count depends on context. For peripheral blood mobilization, counts above about 10–20 CD34+ cells/µL are often used to begin apheresis. For transplant graft dose, a minimum of ~2×10^6 CD34+ cells/kg recipient weight is usually required for engraftment, while ~5×10^6/kg is preferred for faster recovery. Consult your transplant team for individualized targets.

How long are stem cells viable?plus

Viability depends on stem cell type and storage. Freshly collected cells typically last hours to a few days; refrigerated samples are generally viable 24–72 hours. With proper cryopreservation (liquid nitrogen), stem cells can remain functional for decades—commonly 20+ years—with high post‑thaw recovery. Long‑term success hinges on collection quality, cryoprotectants, storage temperature, and thawing protocol.

Is CD34 a tumor marker?plus

CD34 is a cell-surface glycoprotein used to identify hematopoietic stem/progenitor cells and endothelial cells. It is not a specific tumor marker: CD34 is expressed in normal blood-forming and vascular cells and in several tumors (e.g., vascular neoplasms, dermatofibrosarcoma protuberans). Its presence aids diagnosis but must be interpreted with other markers and clinical/pathological context.

What tumors are CD34 positive?plus

CD34 is expressed by hematopoietic progenitors and endothelial cells and is positive in various tumors, notably vascular neoplasms (hemangiomas, angiosarcomas), dermatofibrosarcoma protuberans (strongly CD34+), solitary fibrous tumor, many gastrointestinal stromal tumors (GISTs), spindle cell/pleomorphic lipomas and some other soft‑tissue sarcomas. Immunoprofile must be interpreted with morphology and other markers for accurate diagnosis.

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